Identification of a novel circulating recombinant form (CRF3301B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia

Tee, K.K. and Li, X.J. and Nohtomi, K. and Ng, K.P. and Kamarulzaman, Adeeba and Takebe, Y. (2006) Identification of a novel circulating recombinant form (CRF3301B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia. Journal of Acquired Immune Deficiency Syndromes, 43 (5). pp. 523-529. ISSN 1525-4135

Full text not available from this repository. (Request a copy)

Abstract

A molecular epidemiological investigation was conducted among various risk populations (n = 184) in Kuala Lumpur, Malaysia, in 2003 to 2005, on the basis of nucleotide sequences of protease and reverse transcriptase regions. In addition to circulating HIV-1 strains, including CRF01AE (57.1), subtype B (20.1), and subtype C (0.5), we detected a candidate with a new circulating recombinant form (CRF). We determined four near-full-length nucleotide sequences with identical subtype structure from epidemiologically unlinked individuals of different risk and ethnic groups. In this chimera, two short subtype B segments were inserted into the gag-RT region in a backbone of CRF01AE. The recombinant structure was distinct from previously identified CRF1501B in Thailand. In agreement with the current HIV nomenclature system, this constitutes a novel CRF (CRF3301B). The overall prevalence of CRF3301B is 19.0 (35/184). Although the prevalence of CRF3301B is particularly high among injecting drug users (42.0, 21/50), it is also detected in a substantial proportion of homo-/bisexual males (18.8, 3/16) and heterosexuals (9.8, 9/92). Moreover, unique recombinant forms composed of CRF01AE and subtype B that have a significant structural relationship with CRF3301B were detected in 1.6 (3/184) of study subjects, suggesting an ongoing recombination process in Malaysia. This new CRF seems to be bridging viral transmission between different risk populations in this country.

Item Type: Article
Additional Information: Tee, Kok Keng Li, Xiao-Jie Nohtomi, Kyoko Ng, Kee Peng Kamarulzaman, Adeeba Takebe, Yutaka
Uncontrolled Keywords: Molecular Epidemiological Investigation
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 23 Jan 2013 08:26
Last Modified: 21 Mar 2019 04:35
URI: http://eprints.um.edu.my/id/eprint/4588

Actions (login required)

View Item View Item