Tee, K.K. and Li, X.J. and Nohtomi, K. and Ng, K.P. and Kamarulzaman, Adeeba and Takebe, Y. (2006) Identification of a novel circulating recombinant form (CRF3301B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia. Journal of Acquired Immune Deficiency Syndromes, 43 (5). pp. 523-529. ISSN 1525-4135,
Full text not available from this repository.Abstract
A molecular epidemiological investigation was conducted among various risk populations (n = 184) in Kuala Lumpur, Malaysia, in 2003 to 2005, on the basis of nucleotide sequences of protease and reverse transcriptase regions. In addition to circulating HIV-1 strains, including CRF01AE (57.1), subtype B (20.1), and subtype C (0.5), we detected a candidate with a new circulating recombinant form (CRF). We determined four near-full-length nucleotide sequences with identical subtype structure from epidemiologically unlinked individuals of different risk and ethnic groups. In this chimera, two short subtype B segments were inserted into the gag-RT region in a backbone of CRF01AE. The recombinant structure was distinct from previously identified CRF1501B in Thailand. In agreement with the current HIV nomenclature system, this constitutes a novel CRF (CRF3301B). The overall prevalence of CRF3301B is 19.0 (35/184). Although the prevalence of CRF3301B is particularly high among injecting drug users (42.0, 21/50), it is also detected in a substantial proportion of homo-/bisexual males (18.8, 3/16) and heterosexuals (9.8, 9/92). Moreover, unique recombinant forms composed of CRF01AE and subtype B that have a significant structural relationship with CRF3301B were detected in 1.6 (3/184) of study subjects, suggesting an ongoing recombination process in Malaysia. This new CRF seems to be bridging viral transmission between different risk populations in this country.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Tee, Kok Keng Li, Xiao-Jie Nohtomi, Kyoko Ng, Kee Peng Kamarulzaman, Adeeba Takebe, Yutaka |
| Uncontrolled Keywords: | Molecular Epidemiological Investigation |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 23 Jan 2013 08:26 |
| Last Modified: | 21 Mar 2019 04:35 |
| URI: | http://eprints.um.edu.my/id/eprint/4588 |
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