Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1

Aghafar, M.Z.K.A and Witt, C. and Kamarulzaman, A. and Ismail, R. and Lederman, M.M. and Rodriguez, B. and Senitzer, D. and Lee, S. and Price, P. (2012) Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. Tissue Antigens, 79 (5). pp. 367-371. ISSN 0001-2815

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Abstract

Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.

Item Type: Article
Additional Information: Aghafar, M. Z. K. A. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. M. Rodriguez, B. Senitzer, D. Lee, S. Price, P.
Uncontrolled Keywords: Human leukocyte antigen-G;killer immunoglobulin-like receptors;leukocyte immunoglobulin-like receptor subfamily B member
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 25 Jan 2013 01:50
Last Modified: 25 Jan 2013 01:50
URI: http://eprints.um.edu.my/id/eprint/4583

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