The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia

Tee, K.K.; Saw, T.L.; Pon, C.K.; Kamarulzaman, A.; Ng, K.P. (2005) The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia. Aids Research and Human Retroviruses, 21 (12). pp. 1046-1050. ISSN 0889-2229

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    Abstract

    Earlier studies in the 1990s indicate that human immunodeficiency virus type 1 (HIV-1) subtype B has been the predominant subtype among injecting drug users (IDUs) in Malaysia. More recent studies performed between 2003 and 2004, however, show a high prevalence of unique CRF01AE/B intersubtype recombinants among IDUs. To determine the subtype distribution among IDUs in Kuala Lumpur prior to the emergence of CRF01AE/B intersubtype recombinants, the gag-pol or the reverse transcriptase gene was sequenced from IDUs who were diagnosed as HIV positive between 1993 and 2002. Subtype B was present at 50.0 followed by CRF01AE/B recombinant at 41.7, with more CRF01AE/B recombinants detected between 2000 and 2002. All CRF01AE/B recombinants shared similar recombination patterns. Interestingly, we found that this potential new candidate of circulating recombinant form (CRF) could have emerged as early as the mid-1990s. The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01AE/B intersubtype recombinants among IDUs in Kuala Lumpur.

    Item Type: Article
    Creators:
    1. Tee, K.K.
    2. Saw, T.L.
    3. Pon, C.K.
    4. Kamarulzaman, A.(Department of Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    5. Ng, K.P.
    Journal or Publication Title: Aids Research and Human Retroviruses
    Additional Information: Tee, KK Saw, TL Pon, CK Kamarulzaman, A Ng, KP
    Uncontrolled Keywords: HIV type 1
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 04 Dec 2012 11:06
    Last Modified: 04 Dec 2012 11:06
    URI: http://eprints.um.edu.my/id/eprint/4573

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