The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia

Tee, K.K.; Saw, T.L.; Pon, C.K.; Kamarulzaman, A.; Ng, K.P. (2005) The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia. Aids Research and Human Retroviruses, 21 (12). pp. 1046-1050. ISSN 0889-2229

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    Earlier studies in the 1990s indicate that human immunodeficiency virus type 1 (HIV-1) subtype B has been the predominant subtype among injecting drug users (IDUs) in Malaysia. More recent studies performed between 2003 and 2004, however, show a high prevalence of unique CRF01AE/B intersubtype recombinants among IDUs. To determine the subtype distribution among IDUs in Kuala Lumpur prior to the emergence of CRF01AE/B intersubtype recombinants, the gag-pol or the reverse transcriptase gene was sequenced from IDUs who were diagnosed as HIV positive between 1993 and 2002. Subtype B was present at 50.0 followed by CRF01AE/B recombinant at 41.7, with more CRF01AE/B recombinants detected between 2000 and 2002. All CRF01AE/B recombinants shared similar recombination patterns. Interestingly, we found that this potential new candidate of circulating recombinant form (CRF) could have emerged as early as the mid-1990s. The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01AE/B intersubtype recombinants among IDUs in Kuala Lumpur.

    Item Type: Article
    1. Tee, K.K.
    2. Saw, T.L.
    3. Pon, C.K.
    4. Kamarulzaman, A.(Department of Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    5. Ng, K.P.
    Journal or Publication Title: Aids Research and Human Retroviruses
    Additional Information: Tee, KK Saw, TL Pon, CK Kamarulzaman, A Ng, KP
    Uncontrolled Keywords: HIV type 1
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms azrahani halim
    Date Deposited: 04 Dec 2012 11:06
    Last Modified: 04 Dec 2012 11:06

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