Tee, K.K. and Saw, T.L. and Pon, C.K. and Kamarulzaman, A. and Ng, K.P. (2005) The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia. Aids Research and Human Retroviruses, 21 (12). pp. 1046-1050. ISSN 0889-2229,
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Abstract
Earlier studies in the 1990s indicate that human immunodeficiency virus type 1 (HIV-1) subtype B has been the predominant subtype among injecting drug users (IDUs) in Malaysia. More recent studies performed between 2003 and 2004, however, show a high prevalence of unique CRF01AE/B intersubtype recombinants among IDUs. To determine the subtype distribution among IDUs in Kuala Lumpur prior to the emergence of CRF01AE/B intersubtype recombinants, the gag-pol or the reverse transcriptase gene was sequenced from IDUs who were diagnosed as HIV positive between 1993 and 2002. Subtype B was present at 50.0 followed by CRF01AE/B recombinant at 41.7, with more CRF01AE/B recombinants detected between 2000 and 2002. All CRF01AE/B recombinants shared similar recombination patterns. Interestingly, we found that this potential new candidate of circulating recombinant form (CRF) could have emerged as early as the mid-1990s. The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01AE/B intersubtype recombinants among IDUs in Kuala Lumpur.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Tee, KK Saw, TL Pon, CK Kamarulzaman, A Ng, KP |
| Uncontrolled Keywords: | HIV type 1 |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 04 Dec 2012 03:06 |
| Last Modified: | 04 Dec 2012 03:06 |
| URI: | http://eprints.um.edu.my/id/eprint/4573 |
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