Primus, Phoebe Sussana and Wu, Carol Hsin-Yi and Kao, Chai-Lin and Choo, Yeun-Mun (2024) A New Oxoaporphine and Liriodenine's Anti-Neuroblastoma Potential from the Roots of Polyalthia bullata King. Sains Malaysiana, 53 (2). pp. 359-367. ISSN 0126-6039, DOI https://doi.org/10.17576/jsm-2024-5302-10.
Full text not available from this repository.Abstract
Polyalthia bullata King's root yielded a new compound named 5-methylliridine (1) in addition to six previously identified compounds. These known compounds include liriodenine (2), 11-methoxyliriodenine (3), lysicamine (4), onychine (5), 5-hydroxy-6-methoxyonychine (6), and 8-methoxyeupolauridine (7). The structures of compounds 1-7 were determined through spectroscopic analysis. Liriodenine (2) exhibited a remarkable ability to decrease the cell viability of cancerous N2A cells to 22% within a 24 h timeframe, indicating its potential as an anti-neuroblastoma agent. Molecular docking results additionally suggested that oxoaporphines (1-4) have the potential to act as inhibitors of protein kinases. These findings highlight the therapeutic potential of P. bullata constituents in cancer treatment, particularly neuroblastoma, and contribute to understanding its medicinal properties.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (ST008-2020) |
| Uncontrolled Keywords: | Anti-neuroblastoma; oxoaporphine; protein kinase; Polyalthia bullata King; Tongkat Ali Hitam |
| Subjects: | Q Science > QD Chemistry S Agriculture > S Agriculture (General) |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Nov 2024 08:37 |
| Last Modified: | 08 Nov 2024 08:37 |
| URI: | http://eprints.um.edu.my/id/eprint/45697 |
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