Kumar, Sushmitha Rajeev and Sakthiswary, Rajalingham and Lokanathan, Yogeswaran (2024) Potential Therapeutic Application and Mechanism of Action of Stem Cell-Derived Extracellular Vesicles (EVs) in Systemic Lupus Erythematosus (SLE). International Journal of Molecular Sciences, 25 (4). p. 2444. ISSN 1661-6596, DOI https://doi.org/10.3390/ijms25042444.
Full text not available from this repository.Abstract
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE.
| Item Type: | Article |
|---|---|
| Funders: | Faculty of Medicine |
| Uncontrolled Keywords: | extracellular vesicles (EVs); immunomodulation; inflammation; mesenchymal stromal cells; systemic lupus erythematosus (SLE); autoimmune |
| Subjects: | Q Science > QH Natural history R Medicine > R Medicine (General) |
| Divisions: | Faculty of Engineering > Biomedical Engineering Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Nov 2024 07:56 |
| Last Modified: | 08 Nov 2024 07:56 |
| URI: | http://eprints.um.edu.my/id/eprint/45688 |
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