Azad, Abul Kalam and Lai, Joanne and Sulaiman, Wan Mohd Azizi Wan and Almoustafa, Hassan and Alshehade, Salah Abdalrazak and Kumarasamy, Vinoth and Subramaniyan, Vetriselvan (2024) The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present. Pharmaceutics, 16 (2). p. 160. ISSN 1999-4923, DOI https://doi.org/10.3390/pharmaceutics16020160.
Full text not available from this repository.Abstract
Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness. There are many studies ongoing to overcome this problem. All of this motivated us to conduct this review that discusses the fabrication of polymer-based curcumin-loaded formulation as an advanced drug delivery system and addresses different approaches to overcoming the existing barriers and improving its bioavailability and biodistribution to enhance the therapeutic effects against cancer and other diseases.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | curcumin; encapsulation; targeted drug delivery; colon cancer; absorption; bioavailability |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Nov 2024 04:03 |
| Last Modified: | 08 Nov 2024 04:03 |
| URI: | http://eprints.um.edu.my/id/eprint/45673 |
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