Hamzah, Ainal Mardziah Che and Chew, Ching Hoong and Al-Trad, Esra'a Ibrahim and Puah, Suat Moi and Chua, Kek Heng and Rahman, Nor Iza A. and Ismail, Salwani and Maeda, Toshinari and Palittapongarnpim, Prasit and Yeo, Chew Chieng (2024) Whole genome sequencing of methicillin-resistant Staphylococcus aureus clinical isolates from Terengganu, Malaysia, indicates the predominance of the EMRSA-15 (ST22-SCCmec IV) clone. Scientific Reports, 14 (1). p. 3485. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-024-54182-x.
Full text not available from this repository.Abstract
Despite the importance of methicillin-resistant Staphylococcus aureus (MRSA) as a priority nosocomial pathogen, the genome sequences of Malaysian MRSA isolates are currently limited to a small pool of samples. Here, we present the genome sequence analyses of 88 clinical MRSA isolates obtained from the main tertiary hospital in Terengganu, Malaysia in 2016-2020, to obtain in-depth insights into their characteristics. The EMRSA-15 (ST22-SCCmec IV) clone of the clonal complex 22 (CC22) lineage was predominant with a total of 61 (69.3%) isolates. Earlier reports from other Malaysian hospitals indicated the predominance of the ST239 clone, but only two (2.3%) isolates were identified in this study. Two Indian-origin clones, the Bengal Bay clone ST772-SCCmec V (n = 2) and ST672 (n = 10) were also detected, with most of the ST672 isolates obtained in 2020 (n = 7). Two new STs were found, with one isolate each, and were designated ST7879 and ST7883. From the core genome phylogenetic tree, the HSNZ MRSA isolates could be grouped into seven clades. Antimicrobial phenotype-genotype concordance was high (> 95%), indicating the accuracy of WGS in predicting most resistances. Majority of the MRSA isolates were found to harbor more than 10 virulence genes, demonstrating their pathogenic nature.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Higher Education, Fundamental Research Grant Scheme (FRGS/1/2019/SKK11/UNISZA/02/1) |
| Uncontrolled Keywords: | Health-Care Workers; Mupirocin Resistance; MRSA; Transmission; Hospitals; Emergence; Mortality; Infection; Genes; MECA |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Nov 2024 07:01 |
| Last Modified: | 06 Nov 2024 07:01 |
| URI: | http://eprints.um.edu.my/id/eprint/45632 |
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