Kusamoto, Akari and Harada, Miyuki and Minemura, Ayaka and Matsumoto, Asami and Oka, Kentaro and Takahashi, Motomichi and Sakaguchi, Nanoka and Azhary, Jerilee M.K. and Koike, Hiroshi and Xu, Zixin and Tanaka, Tsurugi and Urata, Yoko and Kunitomi, Chisato and Takahashi, Nozomi and Wada-Hiraike, Osamu and Hirota, Yasushi and Osuga, Yutaka (2024) Effects of the prenatal and postnatal nurturing environment on the phenotype and gut microbiota of mice with polycystic ovary syndrome induced by prenatal androgen exposure: a cross-fostering study. Frontiers in Cell and Developmental Biology, 12. p. 1365624. ISSN 2296-634X, DOI https://doi.org/10.3389/fcell.2024.1365624.
Full text not available from this repository.Abstract
The gut microbiome is implicated in the pathogenesis of polycystic ovary syndrome (PCOS), and prenatal androgen exposure is involved in the development of PCOS in later life. Our previous study of a mouse model of PCOS induced by prenatal dihydrotestosterone (DHT) exposure showed that the reproductive phenotype of PCOS appears from puberty, followed by the appearance of the metabolic phenotype after young adulthood, while changes in the gut microbiota was already apparent before puberty. To determine whether the prenatal or postnatal nurturing environment primarily contributes to these changes that characterize prenatally androgenized (PNA) offspring, we used a cross-fostering model to evaluate the effects of changes in the postnatal early-life environment of PNA offspring on the development of PCOS-like phenotypes and alterations in the gut microbiota in later life. Female PNA offspring fostered by normal dams (exposed to an abnormal prenatal environment only, fostered PNA) exhibited less marked PCOS-like phenotypes than PNA offspring, especially with respect to the metabolic phenotype. The gut microbiota of the fostered PNA offspring was similar to that of controls before adolescence, but differences between the fostered PNA and control groups became apparent after young adulthood. In conclusion, both prenatal androgen exposure and the postnatal early-life environment created by the DHT injection of mothers contribute to the development of PCOS-like phenotypes and the alterations in the gut microbiota that characterize PNA offspring. Thus, both the pre- and postnatal environments represent targets for the prevention of PCOS and the associated alteration in the gut microbiota in later life.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science |
| Uncontrolled Keywords: | androgen; cross-fostering model; delayed effect of prenatal exposure; gastrointestinal microbiome; polycystic ovary syndrome (PCOS) |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Oct 2024 04:24 |
| Last Modified: | 21 Oct 2024 04:24 |
| URI: | http://eprints.um.edu.my/id/eprint/45408 |
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