AbuBakar, Sazaly and Wong, P.F. and Chan, Yoke Fun (2002) Emergence of dengue virus type 4 genotype IIA in Malaysia. The Journal of General Virology, 83 (Pt 10). pp. 2437-42. ISSN 0022-1317, DOI 12237425.
Full text not available from this repository.Abstract
Phylogenetic analyses of the envelope (E) gene sequence of five recently isolated dengue virus type 4 (DENV-4) suggested the emergence of a distinct geographical and temporal DENV-4 subgenotype IIA in Malaysia. Four of the isolates had direct ancestral lineage with DENV-4 Indonesia 1973 and showed evidence of intra-serotypic recombination with the other recently isolated DENV-4, MY01-22713. The E gene of isolate MY01-22713 had strong evidence of an earlier recombination involving DENV-4 genotype II Indonesia 1976 and genotype I Malaysia 1969. These results suggest that intra-serotypic recombination amongst DENV-4 from independent ancestral lineages may have contributed to the emergence of DENV-4 subgenotype IIA in Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Aedes; Animals; Base Sequence; Cell Line; DNA, Viral; |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 10 Mar 2011 01:36 |
| Last Modified: | 23 Dec 2019 04:34 |
| URI: | http://eprints.um.edu.my/id/eprint/454 |
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