Gong, Jingwei and Hou, Leilei and Ching, Yern Chee and Ching, Kuan Yong and Hai, Nguyen Dai and Chuah, Cheng Hock (2024) A review of recent advances of cellulose-based intelligent-responsive hydrogels as vehicles for controllable drug delivery system. International Journal of Biological Macromolecules, 264 (2). p. 130525. ISSN 0141-8130, DOI https://doi.org/10.1016/j.ijbiomac.2024.130525.
Full text not available from this repository.Abstract
To realize the maximum therapeutic activity of medicine and protect the body from the adverse effects of active ingredients, drug delivery systems (DDS) featured with targeted transportation sites and controllable release have captured extensive attention over the past decades. Hydrogels with unique three-dimensional (3D) porous structures present tunable capacity, controllable degradation, various stimuli sensitivity, therapeutic agents encapsulation, and loaded drugs protection properties, which endow hydrogels with bred-in-the-bone advantages as vehicles for drug delivery. In recent years, with the impressive consciousness of the ``back-to-nature'' concept, biomass materials are becoming the `rising star' as the hydrogels building blocks for controlled drug release carriers due to their biodegradability, biocompatibility, and non-toxicity properties. In particular, cellulose and its derivatives are promising candidates for fabricating hydrogels as their rich sources and high availability, and various smart cellulose-based hydrogels as targeted carriers under exogenous such as light, electric field, and magnetic field or endogenous such as pH, temperature, ionic strength, and redox gradients. In this review, we summarized the main synthetic strategies of smart cellulose-based hydrogels including physical and chemical cross-linking, and illustrated the detailed intelligent-responsive mechanism of hydrogels in DDS under external stimulus. Additionally, the ongoing development and challenges of cellulose-based hydrogels in the biomedical field are also presented.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya research grant (ST001-2023) ; (ST078-2022) |
| Uncontrolled Keywords: | Cellulose; Hydrogel; Intelligent response |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering > Department of Chemical Engineering Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Oct 2024 09:00 |
| Last Modified: | 14 Oct 2024 09:00 |
| URI: | http://eprints.um.edu.my/id/eprint/45358 |
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