Awuah, Wireko Andrew and Roy, Sakshi and Tan, Joecelyn Kirani and Adebusoye, Favour Tope and Qiang, Zekai and Ferreira, Tomas and Ahluwalia, Arjun and Shet, Vallabh and Yee, Amanda Leong Weng and Abdul-Rahman, Toufik and Papadakis, Marios (2024) Exploring the current landscape of single-cell RNA sequencing applications in gastric cancer research. Journal of Cellular and Molecular Medicine, 28 (7). e18159. ISSN 1582-1838, DOI https://doi.org/10.1111/jcmm.18159.
Full text not available from this repository.Abstract
Gastric cancer (GC) represents a major global health burden and is responsible for a significant number of cancer-related fatalities. Its complex nature, characterized by heterogeneity and aggressive behaviour, poses considerable challenges for effective diagnosis and treatment. Single-cell RNA sequencing (scRNA-seq) has emerged as an important technique, offering unprecedented precision and depth in gene expression profiling at the cellular level. By facilitating the identification of distinct cell populations, rare cells and dynamic transcriptional changes within GC, scRNA-seq has yielded valuable insights into tumour progression and potential therapeutic targets. Moreover, this technology has significantly improved our comprehension of the tumour microenvironment (TME) and its intricate interplay with immune cells, thereby opening avenues for targeted therapeutic strategies. Nonetheless, certain obstacles, including tumour heterogeneity and technical limitations, persist in the field. Current endeavours are dedicated to refining protocols and computational tools to surmount these challenges. In this narrative review, we explore the significance of scRNA-seq in GC, emphasizing its advantages, challenges and potential applications in unravelling tumour heterogeneity and identifying promising therapeutic targets. Additionally, we discuss recent developments, ongoing efforts to overcome these challenges, and future prospects. Although further enhancements are required, scRNA-seq has already provided valuable insights into GC and holds promise for advancing biomedical research and clinical practice.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | gastric cancer; gene expression profiling; medical oncology; molecular medicine; scRNA-seq; single-cell RNA sequencing; therapeutic targets; tumour heterogeneity; tumour microenvironment |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Oct 2024 07:51 |
| Last Modified: | 14 Oct 2024 07:51 |
| URI: | http://eprints.um.edu.my/id/eprint/45344 |
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