Pan, Jia-Wern and Ragu, Mohana and Chan, Wei-Qin and Hasan, Siti Norhidayu and Islam, Tania and Teoh, Li-Ying and Jamaris, Suniza and See, Mee-Hoong and Yip, Cheng-Har and Rajadurai, Pathmanathan and Looi, Lai Meng and Taib, Nur Aishah Mohd and Rueda, Oscar M. and Caldas, Carlos and Chin, Suet-Feung and Lim, Joanna and Teo, Soo Hwang (2024) Clustering of HR + /HER2-breast cancer in an Asian cohort is driven by immune phenotypes. Breast Cancer Research, 26 (1). p. 67. ISSN 1465-5411, DOI https://doi.org/10.1186/s13058-024-01826-5.
Full text not available from this repository.Abstract
Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast cancer within the Asian population, by analysing the transcriptomic profiles of 934 breast cancer patients from a Malaysian cohort. Our findings reveal that the HR + /HER2- breast cancer samples display a distinct clustering pattern based on immune phenotypes, rather than conforming to the conventional luminal A-luminal B paradigm previously reported in breast cancers from women of European descent. This suggests that the activation of the immune system may play a more important role in Asian HR + /HER2- breast cancer than has been previously recognized. Analysis of somatic mutations by whole exome sequencing showed that counter-intuitively, the cluster of HR + /HER2- samples exhibiting higher immune scores was associated with lower tumour mutational burden, lower homologous recombination deficiency scores, and fewer copy number aberrations, implicating the involvement of non-canonical tumour immune pathways. Further investigations are warranted to determine the underlying mechanisms of these pathways, with the potential to develop innovative immunotherapeutic approaches tailored to this specific patient population.
| Item Type: | Article |
|---|---|
| Funders: | Scientex Foundation, Estee Lauder Companies, Vistage Malaysia, Yayasan PETRONAS, Yayasan Sime Darby, Newton-Ungku Omar Fund (MRC) (MR/P012442/1), Cancer Research UK |
| Uncontrolled Keywords: | Breast-cancer; Immune landscape; Risk-factors; Copy number; DNA-repair; Reveals; Women |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Oct 2024 08:16 |
| Last Modified: | 07 Oct 2024 08:16 |
| URI: | http://eprints.um.edu.my/id/eprint/45297 |
Actions (login required)
 |
View Item |
