Jamaluddin, Nurul Adilla Hayat and Periyasamy, Petrick and Lau, Chee Lan and Ponnampalavanar, Sasheela and Lai, Pauline Siew Mei and Loong, Ly Sia and Sidik, Tg Mohd Ikhwan Tg Abu Bakar and Ramli, Ramliza and Tan, Toh Leong and Kori, Najma and Yin, Mei Kuen and Azman, Nur Jannah and James, Rodney and Thursky, Karin and Mohamed, Isa Naina and Grp, Malaysian NAPSWorking (2024) Assessment of antimicrobial prescribing patterns, guidelines compliance, and appropriateness of antimicrobial prescribing in surgical-practice units: point prevalence survey in Malaysian teaching hospitals. Frontiers in Pharmacology, 15. p. 1381843. ISSN 1663-9812, DOI https://doi.org/10.3389/fphar.2024.1381843.
Full text not available from this repository.Abstract
Objectives: This study sought to investigate the quality of antimicrobial prescribing among adult surgical inpatients besides exploring the determinants of non-compliance and inappropriate prescribing to inform stewardship activities. Methods: A cross-sectional point prevalence study employing Hospital National Antimicrobial Prescribing Survey (Hospital NAPS) was conducted in April 2019 at two teaching hospitals in Malaysia. Results: Among 566 surgical inpatients, 44.2% were receiving at least one antimicrobial, for a total of 339 prescriptions. Antimicrobials belonging to the World Health Organization's Watch group were observed in 57.8% of cases. Both hospitals exhibited similar types of antimicrobial treatments prescribed and administration routes. A significant difference in antimicrobial choice was observed between hospitals (p < 0.001). Hospital with electronic prescribing demonstrated better documentation practice (p < 0.001). Guidelines compliance, 32.8% (p = 0.952) and appropriateness, 55.2% (p = 0.561) did not significantly differ. The major contributors of inappropriateness were incorrect duration, (15%) and unnecessary broad-spectrum coverage, (15.6%). Non-compliance and inappropriate prescribing were found to be 2 to 4 times significantly higher with antimicrobial prophylaxis prescription compared to empirical therapy. Conclusion: Antimicrobial stewardship efforts to improve appropriate surgical prescribing are essential. These initiatives should prioritize surgical prophylaxis prescribing, focusing on reducing unnecessarily prolonged use and broad-spectrum antimicrobials, raising awareness among prescribers and promoting proper documentation.
| Item Type: | Article |
|---|---|
| Funders: | Pfizer Independent Grants for Learning and Change (IGCL) (40867041) |
| Uncontrolled Keywords: | point prevalence; guidelines compliance; appropriateness; surgical; antimicrobial prophylaxis; antimicrobial stewardship |
| Subjects: | R Medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Primary Care Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Oct 2024 07:10 |
| Last Modified: | 07 Oct 2024 07:10 |
| URI: | http://eprints.um.edu.my/id/eprint/45291 |
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