Salimi, Esmaeil and Asim, Mulazim Hussain and Abidin, Muhammad Nidzhom Zainol (2024) Investigating the in-vitro bioactivity, biodegradability and drug release behavior of the newly developed PES/HA/WS biocompatible nanocomposites as bone graft substitute. Scientific Reports, 14 (1). p. 10798. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-024-61586-2.
Full text not available from this repository.Abstract
The nucleation of carbonate-containing apatite on the biomaterials surface is regarded as a significant stage in bone healing process. In this regard, composites contained hydroxyapatite (Ca10(PO4)6(OH)2, HA), wollastonite (CaSiO3, WS) and polyethersulfone (PES) were synthesized via a simple solvent casting technique. The in-vitro bioactivity of the prepared composite films with different weight ratios of HA and WS was studied by placing the samples in the simulated body fluid (SBF) for 21 days. The results indicated that the the surface of composites containing 2 wt% HA and 4 wt% WS was completely covered by a thick bone-like apatite layer, which was characterized by Grazing incidence X-ray diffraction, attenuated total reflectance-Fourier transform infrared spectrometer, field emission electron microscopy and energy dispersive X-ray analyzer (EDX). The degradation study of the samples showed that the concentration of inorganic particles could not influence the degradability of the polymeric matrix, where all samples expressed similar dexamethasone (DEX) release behavior. Moreover, the in-vitro cytotoxicity results indicated the significant cyto-compatibility of all specimens. Therefore, these findings revealed that the prepared composite films composed of PES, HA, WS and DEX could be regarded as promising bioactive candidates with low degradation rate for bone tissue engineering applications.
| Item Type: | Article |
|---|---|
| Funders: | Shahrood University of Technology, Iran |
| Uncontrolled Keywords: | Bioactive film; Hydroxyapatite; Drug delivery; Bone tissue engineering |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Sep 2024 01:59 |
| Last Modified: | 19 Sep 2024 01:59 |
| URI: | http://eprints.um.edu.my/id/eprint/45238 |
Actions (login required)
 |
View Item |
