Exploring the potential of intermetallic alloys as implantable biomaterials: A comprehensive review

Nasiri-Tabrizi, Bahman and Basirun, Wan Jefrey and Walvekar, Rashmi and Yeong, Chai Hong and Phang, Siew Wei (2024) Exploring the potential of intermetallic alloys as implantable biomaterials: A comprehensive review. Biomaterials Advances, 161. p. 213854. ISSN 2772-9508, DOI https://doi.org/10.1016/j.bioadv.2024.213854.

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Official URL: https://doi.org/10.1016/j.bioadv.2024.213854

Abstract

This review delves into the utilization of intermetallic alloys (IMAs) as advanced biomaterials for medical implants, scrutinizing their conceptual framework, fabrication challenges, and diverse manufacturing techniques such as casting, powder metallurgy, and additive manufacturing. Manufacturing techniques such as casting, powder metallurgy, additive manufacturing, and injection molding are discussed, with specific emphasis on achieving optimal grain sizes, surface roughness, and mechanical properties. Post-treatment methods aimed at refining surface quality, dimensional precision, and mechanical properties of IMAs are explored, including the use of heat treatments to enhance biocompatibility and corrosion resistance. The review presents an in-depth examination of IMAs-based implantable biomaterials, covering lab-scale developments and commercial-scale implants. Specific IMAs such as Nickel Titanium, Titanium Aluminides, Iron Aluminides, Magnesium-based IMAs, Zirconium-based IMAs, and High-entropy alloys (HEAs) are highlighted, with detailed discussions on their mechanical properties, including strength, elastic modulus, and corrosion resistance. Future directions are outlined, with an emphasis on the anticipated growth in the orthopedic devices market and the role of IMAs in meeting this demand. The potential of porous IMAs in orthopedics is explored, with emphasis on achieving optimal pore sizes and distributions for enhanced osseointegration. The review concludes by highlighting the ongoing need for research and development efforts in IMAs technologies, including advancements in design and fabrication techniques.

Item Type: Article
Funders: Fundamental Research Grant Scheme (FRGS/1/2019/SKK06/TAYLOR/02/3), Ministry of Education, Malaysia
Uncontrolled Keywords: Intermetallic alloys; Implantable biomaterials; Manufacturing techniques; Post-treatment; Biomedical applications
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Sep 2024 01:45
Last Modified: 19 Sep 2024 01:45
URI: http://eprints.um.edu.my/id/eprint/45136

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