Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays

Apalasamy, Y.D. and Ming, M.F. and Rampal, S. and Bulgiba, A. and Mohamed, Z. (2012) Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays. Brazilian Journal of Medical and Biological Research (REVIEW). 0-0. ISSN 0100-879X, DOI https://doi.org/10.1590/S0100-879X2012007500134 .

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Abstract

The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs revealed the presence of 57 regions with complete LD (D� = 1.0). In addition, we detected the association of rs17817288 with low-density lipoprotein cholesterol. The FTO gene may therefore be involved in lipid metabolism in Malaysian Malays. Two haplotype blocks were present in this region of the FTO gene, but no particular haplotype was found to be significantly associated with an increased risk of obesity in Malaysian Malays

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Department of Social and Preventive Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: FTO gene; SNP; Obesity; Linkage disequilibrium; Haplotypes
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 16 Jan 2013 00:50
Last Modified: 16 Jan 2013 00:50
URI: http://eprints.um.edu.my/id/eprint/4510

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