Ravindar, Lekkala and Hasbullah, Siti Aishah and Rakesh, K.P. and Raheem, Saki and Agustar, Hani Kartini and Ismail, Norzila and Lau, Yee Ling and Hassan, Nurul Izzaty (2024) Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond. European Journal of Medicinal Chemistry, 264. ISSN 0223-5234, DOI https://doi.org/10.1016/j.ejmech.2023.116043.
Full text not available from this repository.Abstract
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds that appear as a significant assembly motif for developing new drug entities. Aminoquinoline moiety has gained significant attention among researchers in the 21stcentury. Considering the biological and pharmaceutical importance of aminoquinoline derivatives, herein, we review the recent developments (since 2019) in various biological activities of the 4-aminoquinoline scaffold hybridized with diverse heterocyclic moieties such as quinoline, pyridine, pyrimidine, triazine, dioxine, piperazine, pyrazoline, piperidine, imidazole, indole, oxadiazole, carbazole, dioxole, thiazole, benzothiazole, pyrazole, phthalimide, adamantane, benzochromene, and pyridinone. Moreover, by gaining knowledge about SARs, structural insights, and molecular targets, this review may help medicinal chemists design cost-effective, selective, safe, and more potent 4-aminoquinoline hybrids for diverse biological activities. © 2023 Elsevier Masson SAS
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant no. FRGS/1/2019/STG01/UKM/02/3], Universiti Kebangsaan Malaysia |
| Uncontrolled Keywords: | 4-Aminoquinolines; Antibacterial; Anticancer; Antimalarial; Antitubercular |
| Subjects: | Q Science > QD Chemistry R Medicine R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Apr 2024 01:33 |
| Last Modified: | 29 Apr 2024 01:33 |
| URI: | http://eprints.um.edu.my/id/eprint/44961 |
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