Wu, Yuan-Seng and Osman, Ahmed I. and Hosny, Mohamed and Elgarahy, Ahmed M. and Eltaweil, Abdelazeem S. and Rooney, David W. and Chen, Zhonghao and Rahim, Nur Syafiqah and Sekar, Mahendran and Gopinath, Subash C. B. and Mat Rani, Nur Najihah Izzati and Batumalaie, Kalaivani and Yap, Pow-Seng (2024) The toxicity of mercury and its chemical compounds: molecular mechanisms and environmental and human health implications: A comprehensive review. ACS Omega, 9 (5). 5100 – 5126. ISSN 2470-1343, DOI https://doi.org/10.1021/acsomega.3c07047.
Full text not available from this repository.Abstract
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of mercury and its chemical compounds. More than 210 recent works of literature are covered in this review. It first delineates the types (covering elemental mercury, inorganic mercury compounds, organic mercury compounds), structures, and sources of mercury. It then discusses the pharmacokinetic profile of mercury, molecular mechanisms of mercury toxicity, and clinical manifestation of acute and chronic mercury toxicity to public health. It also elucidates the mercury toxicity to the environment and human health in detail, covering ecotoxicity, neurotoxicity diseases, neurological diseases, genotoxicity and gene regulation, immunogenicity, pregnancy and reproductive system damage, cancer promotion, cardiotoxicity, pulmonary diseases, and renal disease. In order to mitigate the adverse effects of mercury, strategies to overcome mercury toxicity are recommended. Finally, some future perspectives are provided in order to advance this field of research in the future. © 2024 The Authors. Published by American Chemical Society.
| Item Type: | Article |
|---|---|
| Funders: | Bureau for Cultural & Educational Affairs in London, EU Programmes Body, SEUPB |
| Uncontrolled Keywords: | Toxicity of mercury; Chemical compounds; Molecular mechanisms; Environment; Human health |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jul 2024 04:12 |
| Last Modified: | 03 Jul 2024 04:12 |
| URI: | http://eprints.um.edu.my/id/eprint/44824 |
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