Khor, Yi-Sheng and Wong, Pooi Fong (2024) MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses. Biogerontology, 25 (1). 23 – 51. ISSN 1389-5729, DOI https://doi.org/10.1007/s10522-023-10059-6.
Full text not available from this repository.Abstract
FOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various external and biological stimuli. FOXO3 decides cell fate by modulating cellular senescence, apoptosis and autophagy by transcriptional regulation of genes involved in DNA damage response and oxidative stress resistance. These cellular processes are tightly regulated physiologically, with FOXO3 acting as the hub that integrates signalling networks controlling them. The activity of FOXO3 is influenced by post-translational modifications, altering its subcellular localisation. In addition, FOXO3 can also be regulated directly or indirectly by microRNAs (miRNAs) or vice versa. This review discusses the involvement of various miRNAs in FOXO3-driven cellular responses such as senescence, apoptosis, autophagy, redox and inflammation defence. Given that these responses are linked and influence cell fate, a thorough understanding of the complex regulation by miRNAs would provide key information for developing therapeutic strategy and avoid unintended consequences caused by off-site targeting of FOXO3. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
| Item Type: | Article |
|---|---|
| Funders: | AAALAC [Grant no. IF084-2022], IQ Consortium |
| Uncontrolled Keywords: | Ageing; Cellular senescence; FOXO3; microRNA; Therapeutic strategy |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Jul 2024 00:47 |
| Last Modified: | 11 Jul 2024 00:47 |
| URI: | http://eprints.um.edu.my/id/eprint/44801 |
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