Kong, Peggy and Raja Ahmad, Raja Elina Afzan and Zulkifli, Amirah and Krishnan, Shaliny and Nam, Hui Yin and Kamarul, Tunku (2024) The role of autophagy in mitigating osteoarthritis progression via regulation of chondrocyte apoptosis: A review. Joint Bone Spine, 91 (3). ISSN 1297-319X, DOI https://doi.org/10.1016/j.jbspin.2023.105642.
Full text not available from this repository.Abstract
Osteoarthritis (OA) is the most prevalent chronic joint disease with an immense socioeconomic burden; however, no treatment has achieved complete success in effectively halting or reversing cartilage degradation, which is the central pathophysiological feature of OA. Chondrocytes loss or dysfunction is a significant contributing factor to the progressive cartilage deterioration as these sole resident cells have a crucial role to produce extracellular matrix proteins, thus maintaining cartilage structure and homeostasis. It has been previously suggested that death of chondrocytes occurring through apoptosis substantially contributes to cartilage degeneration. Although the occurrence of apoptosis in osteoarthritic cartilage and its correlation with cartilage degradation is evident, the causes of chondrocyte apoptosis leading to matrix loss are still not well-understood. Autophagy, an intracellular degradative mechanism that eliminates dysfunctional cytoplasmic components to aid cell survival in unfavourable conditions, is a potential therapeutic target to inhibit chondrocyte apoptosis and reduce OA severity. Despite accumulating evidence indicating significant cytoprotective effects of autophagy against chondrocyte apoptosis, the mechanistic link between autophagy and apoptosis in chondrocytes remains to be further explored. In this review, we summarize the relevant mechanistic events that perpetuate chondrocyte apoptosis and highlight the prominent role of autophagy in modulating these events to mitigate OA progression.(c) 2023 Socie ` te ` franc, aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme FRGS [Grant no. FP089-2019A, FRGS/1/2019/SKK08/UM/02/32], Ministry of Higher Education, Malaysia |
| Uncontrolled Keywords: | Aging; Cartilage; Cell death; Endoplasmic reticulum stress; Inflammation; Mitochondria |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Orthopaedic Surgery Department Faculty of Medicine > Physiology Department Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Apr 2024 03:59 |
| Last Modified: | 25 Apr 2024 03:59 |
| URI: | http://eprints.um.edu.my/id/eprint/44314 |
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