Loong, Shih Keng and Liam, Chong Kin and Karunakaran, Rina and Tan, Kim-Kee and Mahfodz, Nur Hidayana and AbuBakar, Sazaly (2024) Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: A case report. Journal of International Medical Research, 52 (1). ISSN 0300-0605, DOI https://doi.org/10.1177/03000605231214464.
Full text not available from this repository.Abstract
An increasing number of reports have described the pathogenic nature of several non-classical Bordetella spp. Among them, Bordetella hinzii and Bordetella pseudohinzii have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of B. hinzii and B. pseudohinzii from the sputum of a woman in her early 60s with extensive bronchiectasis who presented with fever and brown colored sputum. The isolate had initially been identified as Bordetella avium by API 20NE, the identification system for non-enteric Gram-negative rod bacteria. Sequencing of the 16S rDNA, ompA, nrdA, and genes used in the Bordetella multilocus sequence typing scheme could not resolve the identity of this Bordetella isolate. Whole-genome single nucleotide polymorphism analysis positioned the isolate between B. hinzii and B. pseudohinzii in the phylogenetic tree, forming a distinct cluster. Whole-genome sequencing enabled the further identification of this rare organism, and should be considered for wider applications, especially the confirmation of organism identity in the clinical diagnostic microbiology laboratory.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia; Dana Langganan Sukuk Pakej Rangsangan Ekonomi Prihatin Rakyat (SUKUK PRIHATIN)-Fasa 2 [PPUM/RDI/400/09/001/21], Medical Microbiology Diagnostic Laboratory, UMMC |
| Uncontrolled Keywords: | Bordetellae; bronchiectasis; case report; Malaysia; respiratory tract infection; whole-genome single nucleotide polymorphism |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Medicine Department Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Jun 2024 09:16 |
| Last Modified: | 20 Jun 2024 09:16 |
| URI: | http://eprints.um.edu.my/id/eprint/44200 |
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