Al-Maweri, Sadeq A. and Alhajj, Mohammed Nasser and Anweigi, Lamyia and Ashraf, Sajna and Halboub, Esam and Salleh, Nosizana Mohd and Alanazi, Rawan H. and Nassani, Mohammad Zakaria and Noushad, Mohammed and Al Khabuli, Jumma O. and Shamala, Anas (2024) Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: A systematic review and meta-analysis. BMC Oral Health, 24 (1). ISSN 1472-6831, DOI https://doi.org/10.1186/s12903-023-03789-z.
Full text not available from this repository.Abstract
BackgroundPhotodynamic therapy (PDT) has been recently proposed as a promising alternative therapy for Denture Stomatitis (DS). The present systematic review and meta-analysis investigated the current available evidence regarding the efficacy of PDT in the management of DS.Materials and methodsPubMed, Scopus, Web of Science, Google Scholar, and ProQuest were searched up to June 7, 2023. All relevant clinical trials were included. RevMan software was used for the statistical analyses.ResultsElven randomized clinical trials (460 DS patients) were included. Eight studies assessed the efficacy of PDT vs. topical antifungal therapy, while three studies assessed the adjunctive use of PDT (PDT + antifungal therapy) vs. topical antifungal therapy alone. The results revealed comparable efficacy of PDT and conventional antifungal therapy on candida colonization at 15 days (MD: 0.95, 95% CI: -0.28, 2.19, p = 0.13) and at the end of follow-up (MD: -0.17, 95% CI: -1.33, 0.98, p = 0.77). The pooled two studies revealed relatively better efficacy of adjunctive use of PDT with antifungal therapy on candida colonization compared to antifungal therapy alone at 15 days (MD: -6.67, 95% CI: -15.15, 1.82, p = 0.12), and at the end of follow-up (MD: -7.14, 95% CI: -19.78, 5.50, p = 0.27). Additionally, the results revealed comparable efficacy of PDT and topical antifungal therapy on the clinical outcomes.ConclusionsPDT might be considered a viable option for DS either as an adjunct or as an alternative to the topical antifungal medications. Further studies with adequate sample sizes and standardized PDT parameters are warranted.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Photodynamic therapy; Denture stomatitis; Management; Systematic review |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Jun 2024 03:35 |
| Last Modified: | 14 Jun 2024 03:35 |
| URI: | http://eprints.um.edu.my/id/eprint/44167 |
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