Al-Ani, Ahmad Habeeb Hattab Dala Ali and Othman, Noordin and Hassali, Mohamed Azmi and Ibrahim, Baharudin (2022) Adequacy of empiric antibiotics therapy and its impact on outcomes in adult critically Ill sepsis patients: a review. Malaysian Journal of Medical Sciences, 29 (5). 17 – 23. ISSN 1394195X, DOI https://doi.org/10.21315/mjms2022.29.5.3.
Full text not available from this repository.Abstract
Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was designed to summarise the available evidences regarding the adequacy of the empiric antimicrobial therapy (EAMT), its predictors and its impact on the outcomes in intensive care unit (ICU) sepsis patients. Providing an adequate EAMT is considered one of the cornerstones of sepsis management as it has been found to be associated with better survival and is a good predictor for shorter ICU-length-of-stay. In contrast, inadequate EAMT in sepsis patients is associated with poor clinical outcomes including increased mortality and prolonged hospital stay. Evidence from this review suggest that it is important to identify determinants of inadequate EAMT to optimise the antimicrobial therapy provided to sepsis patients. Predictors of inadequate EAMT included co-morbidities (cancer), source and type of infection, higher Acute Physiology and Chronic Health Evaluation (APACHI-II) score and long hospital stay prior to the infection. As EAMT is considered as one of the effective treatment strategies to prevent sepsis associated death, healthcare providers should ensure the adequate antimicrobial therapy is provided for sepsis patients to improve and optimise their management. © 2022, Penerbit Universiti Sains Malaysia. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antibiotic therapy; APACHE; Critically ill patient; Empiricism; Health care personnel; Hospitalization; Human; Immune response; Intensive care unit; Length of stay; Mortality rate; Outcome assessment; Review; Sepsis; Septic shock |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Clinical Pharmacy and Pharmacy Practice |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Dec 2023 07:35 |
| Last Modified: | 28 Dec 2023 07:35 |
| URI: | http://eprints.um.edu.my/id/eprint/43891 |
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