Raman, Sivaraj and Shafie, Asrul Akmal and Abraham, Mannil Thomas and Kiong, Shim Chen and Maling, Thaddius Herman and Rajendran, Senthilmani and Cheong, Sok Ching (2022) Health-Related Quality of Life among Patients with Oral Potentially Malignant Disorder and Oral Cancer in Malaysia. Archives of Orofacial Sciences, 17 (1). 101 -111. ISSN 1823-8602, DOI https://doi.org/10.21315/aos2022.1701.OA06.
Full text not available from this repository.Abstract
Presently there is a lack of health-related quality of life (HRQOL) measure and its corresponding utility values for oral cancer and oral potentially malignant disorders (OPMD). This limits patient-centered outcomes for cost-effectiveness evaluations. The study aimed to determine post-treatment HRQOL of patients and ascertained differences between OPMD, early and late-stage oral cancer. A crosssectional survey was conducted among patients in oral maxillofacial specialist clinics in two public tertiary hospitals. Consented participants were required to complete the EQ-5D-5L questionnaire with the EQ Visual Analogue System (VAS). Kruskal-Wallis test was used to explore differences in values between stages. Multiple linear regression was used to explore factors that influenced the HRQOL. A total of 50 OPMD and 52 oral cancer patients were surveyed. The mean EQ-5D-5L health utility values was 0.842 (n = 50, SD = 0.139), 0.822 (n = 10, SD = 0.150) and 0.626 (n = 42, SD = 0.310) for OPMD, early- and late-stage cancer, respectively. The mean values of the EQ-5D-5L index and EQ-VAS scale showed significant differences between groups and between early- and late-stage cancer with good discriminative properties. Results of the multiple linear regression indicated that ethnicity, income, residency, diagnosis, and treatment modality were able to significantly account for 25 of EQ-5D-5L utility values, F(10,91) = 3.83, p < 0.001, R2 = 0.360. Indian ethnicity, rural location, income less than RM4,360, late-stage cancer, and multi-modal therapies were all predictors of poorer HRQOL. This study evidenced disease severity and treatment modality to greatly impact the HRQOL of patients, in addition to socio-demographic factors such as ethnicity and income. © 2022. Penerbit Universiti Sains Malaysia. All Rights Reserved.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant No: FRGS/1/2018/ SKK14/USM/02/1] |
| Uncontrolled Keywords: | Inequality; Oral Cancer; Oral Potentially Malignant Disorders; Precancer; Quality of Life |
| Subjects: | R Medicine > RK Dentistry > Oral surger |
| Divisions: | Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Dec 2023 06:59 |
| Last Modified: | 28 Dec 2023 06:59 |
| URI: | http://eprints.um.edu.my/id/eprint/43804 |
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