Kaur, Jesminder and Salehen, Nur’Ain and Norazit, Anwar and Rahman, Amirah Abdul and Nik Abd. Murad, Nor Azian Abdul and Rahman, Nik Mohd Afizan and Ibrahim, Kamariah (2022) Tumor suppressive effects of GAS5 in cancer cells. Non-coding RNA, 8 (3). ISSN 2311-553X, DOI https://doi.org/10.3390/ncrna8030039.
Full text not available from this repository.Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review arti-cle focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [Grant No: FRGS/1/2019/STG03/UM/02/4] |
| Uncontrolled Keywords: | lncRNA; Growth-arrest specific transcript; 5GAS5; Tumor suppressor; Polymorphism |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Oct 2023 07:52 |
| Last Modified: | 20 Oct 2023 07:52 |
| URI: | http://eprints.um.edu.my/id/eprint/43620 |
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