Abdulrahman, Mahmoud Dogara and Zakariya, Ali Muhammad and Hama, Harmand A. and Hamad, Saber W. and Al-Rawi, Sawsan S. and Bradosty, Sarwan W. and Ibrahim, Ahmad H. (2022) Ethnopharmacology, biological evaluation, and chemical composition of Ziziphus spina - Christi (L.) Desf.: A Review. Advances in Pharmacological and Pharmaceutical Sciences, 2022. ISSN 26334682, DOI https://doi.org/10.1155/2022/4495688.
Full text not available from this repository.Abstract
Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established. © 2022 Mahmoud Dogara Abdulrahman et al.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Anthocyanin; Antiinflammatory agent; Aurantiin; Caffeic acid; Catechin; Chlorogenic acid; Cyclopeptide; Epicatechin; Ferulic acid; Flavonoid; Gallocatechin; Hyperin; Phytochemical; Plant extract; Polyphenol; Procyanidin; Quercetin; Quercetin derivative; Resveratrol; Rosmarinic acid; Rutoside; Sinapic acid; Unclassified drug; Volatile agent; Ziziphus spina-christi extract; Antibacterial activity; Antidiabetic activity; Antidiarrheal activity; Antifungal activity; Antiinflammatory activity; Antimalarial activity; Antineoplastic activity; Antiobesity activity; Antioxidant activity; Antiparasitic activity; Antiviral activity; BioMed Central; Chemical composition; Drug efficacy; Drug safety; Drug screening; Ethnopharmacology; Insecticidal activity; Liver; Medline; Nonhuman; Plant leaf; Review; ScienceDirect; Scopus; Search engine; SpringerLink; Web of Science; Ziziphus spina-christi |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Oct 2023 03:30 |
| Last Modified: | 30 Oct 2023 03:30 |
| URI: | http://eprints.um.edu.my/id/eprint/43587 |
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