Shalauddin, Md and Akhter, Shamima and Wan Jeffrey, Basirun and Sanghiran Lee, Vannajan and Johan, Mohammad Rafie (2022) A metal free nanosensor based on nanocellulose-polypyrrole matrix and single-walled carbon nanotube: Experimental study and electroanalytical application for determination of paracetamol and ciprofloxacin. Environmental Nanotechnology Monitoring and Management, 18. ISSN 2215-1532, DOI https://doi.org/10.1016/j.enmm.2022.100691.
Full text not available from this repository.Abstract
In the present work, a highly selective and metal-free electrochemical sensor was fabricated from the fusion of nanocellulose and polypyrrole (NNC-PPY), incorporated with single-walled carbon nanotubes (SWCNTs) via drop-casting method for the simultaneous determination of paracetamol (PCM) and ciprofloxacin (CPR). The screen printed electrode (SPE) modified with NNC-PPY/SWCNTs shows outstanding electrocatalytic performance towards the redox reaction of PCM and oxidation of CPR. The nanocomposite was investigated by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), differential thermal analysis (DTA) and Brunauer-Emmett-Teller (BET) analysis, while the electrochemical performances were investigated by cyclic voltammetry (CV), square-wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). The molecular interactions and binding energy of the prepared NNC-PPY/SWCNTs nanocomposite with PCM and CPR were studied by molecular dynamic simulation (MDs). The fabricated NNC-PPY/SWCNTs/SPE sensor showed dynamic linear range of 0.05–40.0 µM and 1–50 µM for PCM and CPR and a limit of detection (LOD) of 0.072 nM and 0.196 nM, with high sensitivity of 50.341 µA µM−1 cm−2 and 18.610 µA µM−1 cm−2, for PCM and CPR respectively. Furthermore, this fabricated sensor was implemented successfully for the simultaneous determination of PCM and CPR from water samples, biological fluids and pharmaceutical preparations. © 2022 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant No: IIRG010B-2019, NANOCAT-2020], Universiti Malaya |
| Uncontrolled Keywords: | Ciprofloxacin; Molecular dynamic simulation; Nanocellulose – polypyrrole; Paracetamol; Screen printed electrode; Single-walled carbon nanotubes |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 31 Oct 2023 02:53 |
| Last Modified: | 31 Oct 2023 02:53 |
| URI: | http://eprints.um.edu.my/id/eprint/43506 |
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