Sugiharto and Winarni, Dwi and Wibowo, Anjar Tri and Islamatasya, Ufairanisa and Bhakti, Idqa Nurtri and Nisa, Nabilatun and Tan, Boon Chin and Manuhara, Yosephine Sri Wulan (2022) Gynura procumbens adventitious root extract altered expression of antioxidant genes and exert hepatoprotective effects against cadmium-induced oxidative stress in mice. HAYATI Journal of Biosciences, 29 (4). 479 – 486. ISSN 19783019, DOI https://doi.org/10.4308/hjb.29.4.479-486.
Full text not available from this repository.Abstract
Exposure to cadmium (Cd) could increase of reactive oxygen species (ROS) and changes in expression of antioxidant genes. Gynura procumbens is a medicinal plant that is rich in phenolic and flavonoid compounds. The aimed of study to evaluate the hepatoprotective effect of G. procumbens adventitious root (GAR) extract against Cd toxicity, especially expression rate of hepatic antioxidant genes. Twenty-five male mice were treated as follows: P1 (control), P2 (Cd100mg/L), P3 (GAR100mg/L + Cd100mg/L), P4 (GAR200mg/L + Cd100mg/L), and P5 (GAR300mg/L + Cd100mg/L). The samples (blood and liver) were collected for analysis of malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities, and their relative gene expression were determined. The hematological assay showed Cd-treated administered with GAR extract increased the number of red blood cells (RBC), haemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular haemoglobin (MCH), but reduced the level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, the GAR extract decreased the MDA production, but increased the activities of SOD and CAT. These enzymatic activities were positively correlated with their respective gene transcripts. Our study revealed that GAR extract administration showed marked hepatoprotective effects against Cd-induced oxidative stress. © 2022, Bogor Agricultural University. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Kementerian Pendidikan dan Kebudayaan [Grant No; 853/UN3.14/PT/2020], Universitas Airlangga [Grant No; 1408/UN3/2019] |
| Uncontrolled Keywords: | Antioxidant; Cadmium; Gene expression; Gynura procumbens; Health care; Hepatoprotective |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Nov 2023 03:14 |
| Last Modified: | 06 Nov 2023 03:14 |
| URI: | http://eprints.um.edu.my/id/eprint/43491 |
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