Winarni, Dwi and Husna, Fitria Nikmatul and Syadzha, Muhammad Farraz and Susilo, Raden Joko Kuncoroningrat and Hayaza, Suhailah and Ansori, Arif Nur Muhammad and Alamsjah, Mochammad Amin and Amin, Muhamad Nur Ghoyatul and Wulandari, Pugar Arga Christina and Pudjiastuti, Pratiwi and Awang, Khalijah (2022) Topical administration effect of Sargassum Duplicatum and Garcinia Mangostana extracts combination on open wound healing process in diabetic mice. Scientifica, 2022. pp. 113-122. ISSN 2090-908X, DOI https://doi.org/10.1155/2022/9700794.
Full text not available from this repository.Abstract
This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3-4 months, 30-40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice. © 2022 Dwi Winarni et al.
| Item Type: | Article |
|---|---|
| Funders: | Strengthening Research and Development, Ministry of Research Technology [Grent No: 483/UN3.15/PT/2021] |
| Uncontrolled Keywords: | Cardiology; Diseases; Finite element method; Pathology; Titanium compounds; Classifieds; Electro-mechanical; Heart disease; Left ventricular; Left ventricular hypertrophies; Left ventricular remodeling; Mechanical finite element modeling; Structure functions; Wall structure; Wall thickening; Strain |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Nov 2023 02:53 |
| Last Modified: | 02 Nov 2023 02:53 |
| URI: | http://eprints.um.edu.my/id/eprint/43439 |
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