Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions

Siar, C.H.; Oo, V.P.A.; Nagatsuka, H.; Nakano, K.; Ng, K.H.; Kawakami, T. (2009) Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions. European Journal of Medical Research, 14 (7). pp. 315-319. ISSN 0949-2321

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    Abstract

    Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15) and severe dysplasia (13/20; 65), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p<0.05). CD105 demonstrated increase neo-vascularization in all dysplasia grades (p<0.05). Conclusions: These preliminary Findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index.

    Item Type: Article
    Creators:
    1. Siar, C.H.
    2. Oo, V.P.A.
    3. Nagatsuka, H.
    4. Nakano, K.
    5. Ng, K.H.
    6. Kawakami, T.
    Journal or Publication Title: European Journal of Medical Research
    Additional Information: ISI Document Delivery No.: 495YR Times Cited: 5 Cited Reference Count: 14 Cited References: Barnes LEJ, 2005, WHO CLASSIFICATION T Bouquot J. E., 2006, CURR DIAGN PATHOL, V12, P11, DOI 10.1016/j.cdip.2005.10.008 Carlile J, 2001, J ORAL PATHOL MED, V30, P449, DOI 10.1034/j.1600-0714.2001.030008449.x FOLKMAN J, 1992, J BIOL CHEM, V267, P10931 Hirsch FR, 2002, EUR RESPIR J, V19, P1151, DOI 10.1183/09031936.02.00294102 Hirsch FR, 2001, CLIN CANCER RES, V7, P5 Keith RL, 2000, CLIN CANCER RES, V6, P1616 Kujan O, 2006, ORAL ONCOL, V42, P987, DOI 10.1016/j.oraloncology.2005.12.014 Lodi G, 2005, ORAL SURG ORAL MED O, V100, P164, DOI 10.1016/j.tripleo.2004.06.076 Macluskey M, 2000, J PATHOL, V191, P368, DOI 10.1002/1096-9896(2000)9999:9999<::AID-PATH652>3.3.CO;2-P Pazouki S, 1997, J PATHOL, V183, P39, DOI 10.1002/(SICI)1096-9896(199709)183:1<39::AID-PATH1088>3.3.CO;2-C Reibel J, 2003, CRIT REV ORAL BIOL M, V14, P47 Shibuya K, 2003, THORAX, V58, P989, DOI 10.1136/thorax.58.11.989 WEIDNER N, 1993, AM J PATHOL, V143, P401 Siar, C. H. Oo, V. P. A. Nagatsuka, H. Nakano, K. Ng, K. H. Kawakami, T. University of Malaya VoteF0209/2003A This study was funded by the University of Malaya Vote F0209/2003A. I holzapfel verlag gmbh Munich
    Uncontrolled Keywords: Oral precursor lesions angiogenic squamous dysplasia immunohistochemistry CD31, CD34 CD105 lung-cancer tumor progression malignant-transformation possible relevance high-risk tissues
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Ms Nursyafiqah Abd Malek
    Date Deposited: 10 Jan 2013 08:10
    Last Modified: 10 Jan 2013 08:10
    URI: http://eprints.um.edu.my/id/eprint/4336

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