Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1
Siar, C.H.; Nakano, K.; Ng, K.H.; Tomida, M.; Nagatsuka, H.; Kawakami, T. (2010) Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. European Journal of Medical Research, 15 (4). pp. 180-184. ISSN 0949-2321
Background: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. Case report: This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histopathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2. Conclusions: Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.
|Item Type: ||Article|
- Siar, C.H.
- Nakano, K.
- Ng, K.H.
- Tomida, M.
- Nagatsuka, H.
- Kawakami, T.
|Journal or Publication Title: ||European Journal of Medical Research|
|Additional Information: ||ISI Document Delivery No.: 598JG Times Cited: 5 Cited Reference Count: 25 Cited References: Artavanis-Tsakonas S, 1999, SCIENCE, V284, P770, DOI 10.1126/science.284.5415.770 BADEN E, 1993, ORAL SURG ORAL MED O, V75, P733, DOI 10.1016/0030-4220(93)90432-4 Chuah KS, 2009, J HARD TISSUE BIOL, V18, P63 HAN PP, 2006, J HARD TISUE BIOL, V15, P46, DOI 10.2485/jhtb.15.46 HAN PP, 2007, J HARD TISSUE BIOL, V16, P36 HEIKINHEIMO K, 2006, J HARD TISSUE BIOL, V15, P1, DOI 10.2485/jhtb.15.1 Inoue M, 2008, J HARD TISSUE BIOL, V17, P23, DOI 10.2485/jhtb.17.23 KAWAKAMI T, 2009, CELL DIFFER, P1 Kawai T, 2008, CURRENT EXPERIMENTAL STUDY FOR TREATMENT OF CLEFT LIP AND PALATE, P1 Kim K, 2007, J ORAL MAXIL SURG, V65, P1227, DOI 10.1016/j.joms.2006.05.051 Kumamoto H, 2008, J ORAL PATHOL MED, V37, P228, DOI 10.1111/j.1600-0714.2007.00629.x LEIDER AS, 1989, ORAL SURG ORAL MED O, V68, P175, DOI 10.1016/0030-4220(89)90189-8 Leong KG, 2006, BLOOD, V107, P2223, DOI 10.1182/blood-2005-08-3329 Miele L, 2006, CLIN CANCER RES, V12, P1074, DOI 10.1158/1078-0432.CCR-05-2570 Mitsiadis TA, 2005, ARCH ORAL BIOL, V50, P137, DOI 10.1016/j.archoralbio.2004.10.006 NAGATSUKA H, 2009, ORAL MED PATHOL, V13, P81 Nakano K, 2008, EUR J MED RES, V13, P476 Nakano K, 2008, ORAL MED PATHOL, V12, P53, DOI 10.3353/omp.12.53 Nakano K, 2008, J HARD TISSUE BIOL, V17, P79 Oliveira JAGP, 2006, J ORAL MAXIL SURG, V64, P1325, DOI 10.1016/j.joms.2006.04.036 PULLON PA, 1975, ORAL SURG ORAL MED O, V40, P616, DOI 10.1016/0030-4220(75)90372-2 REICHART PA, 2005, WHO CLASSIFICATION T, P301 Ruhin B, 2007, INT J ORAL MAX SURG, V36, P864, DOI 10.1016/j.ijom.2007.03.002 SIAR CH, 2006, ORAL MED PATHOL, V11, P35 TATEMOTO Y, 1989, ORAL SURG ORAL MED O, V67, P63, DOI 10.1016/0030-4220(89)90303-4 Siar, C. H. Nakano, K. Ng, K. H. Tomida, M. Nagatsuka, H. Kawakami, T. University of MalayaFS170/2008C; Japan Society for the Promotion of Science20592349 This research was supported jointly by the University of Malaya Research Grant FS170/2008C and Grant-in Aid for Scientific Research (C) (20592349) from the Japan Society for the Promotion of Science. I holzapfel verlag gmbh Munich|
|Uncontrolled Keywords: ||Solitary odontogenic tumor Notch signaling immunohistochemistry cytodifferentiation ameloblastomas neoplasms|
|Subjects: ||R Medicine > RK Dentistry|
|Divisions: ||Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology|
|Depositing User: ||Ms Nursyafiqah Abd Malek|
|Date Deposited: ||10 Jan 2013 08:09|
|Last Modified: ||10 Jan 2013 08:09|
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