Risk of the contralateral mucosa in patients with oral potentially malignant disorders

Siar, C.H.; Mah, M.C.; Gill, P.P. (2011) Risk of the contralateral mucosa in patients with oral potentially malignant disorders. Asian Pacific Journal of Cancer Prevention, 12 (3). pp. 631-635. ISSN 1513-7368

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    Abstract

    Background: It is known that abnormal changes may occur in any part of the oral mucous membrane exposed to a carcinogen. Therefore patients with oral potentially malignant disorders (PMDs) are at risk of developing similar lesions at multiple sites. Objectives: To determine the risk of the contralateral mucosa in patients presenting with oral PMDs. Materials and methods: Sixty individuals with PMDs were selected for this study. These comprised 32 (53.3) Indians, 23 (38.3) Chinese, four (6.7) Malays and one (1.7) Nepalese. All selected cases had histopathological confirmation of their primary existing lesion as inclusion criteria. Cases that subsequently presented with a lesion in the corresponding anatomical site also underwent scalpel incisional biopsy on this second lesion to verify its diagnosis. The remaining cases that presented with unilateral PMDs at the time of study were subjected to a cytobrush biopsy on the normal looking contralateral mucosa. Results: A total of 70 primary PMDs were detected in 60 patients. The most common PMD found was oral lichen planus (n=40, 57.1). Of the 60 patients studied, 28 (46.6) exhibited bilateral lesions either synchronously (n=21, 35.0) or metachronously (n=7, 11.6). The remaining cases that had undergone cytobrush biopsy on the corresponding anatomical site yielded normal cytological results. Conclusions: Present findings demonstrated that patients presenting with PMDs in the upper aerodigestive tract are at a greater risk of developing a second lesion most probably in the contralateral anatomical site.

    Item Type: Article
    Creators:
    1. Siar, C.H.
    2. Mah, M.C.
    3. Gill, P.P.
    Journal or Publication Title: Asian Pacific Journal of Cancer Prevention
    Additional Information: ISI Document Delivery No.: 798AR Times Cited: 1 Cited Reference Count: 28 Cited References: Cabay RJ, 2007, J ORAL PATHOL MED, V36, P255, DOI 10.1111/j.1600-0714.2007.00506.x Hamadah O, 2010, BRIT J ORAL MAX SURG, V48, P503, DOI 10.1016/j.bjoms.2009.08.027 LIM GCC, 2008, CANC INCIDENCE PENIN, P1 Lim JSM, 2009, ASIAN PAC J CANCER P, V10, P1071 Lo Muzio L, 1998, ORAL ONCOL, V34, P239, DOI 10.1016/S1368-8375(98)80001-8 Mattsson U, 2002, CRIT REV ORAL BIOL M, V13, P390 Mignogna MD, 2006, ORAL ONCOL, V42, P819, DOI 10.1016/j.oraloncology.2005.11.022 Napier SS, 2008, J ORAL PATHOL MED, V37, P1, DOI 10.1111/j.1600-0714.2007.00579.x Ng KH, 1992, P SCI SEM IMR 90 ANN, P103 Porter SR, 1998, BRIT DENT J, V185, P72, DOI 10.1038/sj.bdj.4809732 Potter TJ, 2003, J ORAL MAXIL SURG, V61, P674, DOI 10.1053/joms.2003.50136 Rad M, 2009, ORAL SURG ORAL MED O, V107, P796, DOI 10.1016/j.tripleo.2009.02.020 Ram S, 2005, INT J ORAL MAX SURG, V34, P521, DOI 10.1016/j.ijom.2004.10.008 Reibel J, 2003, CRIT REV ORAL BIOL M, V14, P47 SIAR CH, 1987, ORAL SURG ORAL MED O, V63, P216, DOI 10.1016/0030-4220(87)90315-X Siar CH, 1990, ASIAN MED J, V33, P697 Siar CH, 2009, EUR J MED RES, V14, P315 Silverman S, 2001, J AM DENT ASSOC, V132, p7S Sitheeque MAM, 2003, CRIT REV ORAL BIOL M, V14, P253 SLAUGHTER DP, 1953, CANCER, V6, P963, DOI 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q Tamamura R, 2006, VIRCHOWS ARCH, V449, P358, DOI 10.1007/s00428-006-0260-z Thomson PJ, 2002, INT J ORAL MAX SURG, V31, P262, DOI 10.1054/ijom.2002.0220 van der Meij EH, 2003, ORAL SURG ORAL MED O, V96, P164, DOI 10.1016/S1079-2104(03)00305-6 van der Waal I, 2010, ORAL ONCOL, V46, P423, DOI 10.1016/j.oraloncology.2010.02.016 VANWYK CW, 1990, J ORAL PATHOL MED, V19, P182 Warnakulasuriya S, 2008, J ORAL PATHOL MED, V37, P127, DOI 10.1111/j.1600-0714.2007.00584.x Yaacob Hashim B, 2002, J Oral Sci, V44, P65 Zain RB, 1997, COMMUNITY DENT ORAL, V25, P377, DOI 10.1111/j.1600-0528.1997.tb00959.x Siar, Chong Huat Mah, Michelle Clare Gill, Praveen Preet Asian pacific organization cancer prevention Gyeonggi-do
    Uncontrolled Keywords: Oral potentially malignant disorder oral mucosa clinical study screening of-the-literature lichen-planus lesions carcinoma cancer surveillance leukoplakia prognosis collagen criteria
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Ms Nursyafiqah Abd Malek
    Date Deposited: 10 Jan 2013 08:04
    Last Modified: 10 Jan 2013 08:04
    URI: http://eprints.um.edu.my/id/eprint/4325

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