Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population

Siar, C.H.; Lau, S.H.; Ng, K.H. (2012) Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population. Journal of Oral and Maxillofacial Surgery, 70 (3). pp. 608-615. ISSN 0278-2391

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      Abstract

      Purpose: Ameloblastoma of the human jaw is an uncommon but clinically significant odontogenic epithelial neoplasm. The aim was to analyze the clinicopathologic characteristics of ameloblastoma in a Malaysian population. Materials and Methods: This is a retrospective study (1993 through 2008) of consecutive ameloblastoma cases accessioned in 2 main oral pathology diagnostic centers: the Unit of Stomatology, Institute for Medical Research and the Department of Oral Pathology, Oral Medicine, and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. Data on patient demographics, tumor location, symptomology, duration, radiographic appearance, preoperative diagnosis, clinicopathologic subtypes, treatment, and recurrence were analyzed. Results: Three hundred forty cases of ameloblastoma were reviewed. These were from 197 male patients (57.9) and 143 female patients (42.1), with a male-to-female ratio of 1.4:1. A wide age range (7 to 85 years), mean onset age of 30.3 +/- 16.3 years, and peak incidence in the second decade of life were recorded. Most were mandibular tumors (n = 311/340, 91.5). These consisted of 95 (28) unicystic ameloblastomas, 221 (65) solid/multicystic ameloblastomas, 22 (6.4) desmoplastic ameloblastoma, and 2 (0.6) peripheral ameloblastomas. Unicystic ameloblastoma (41.1) and solid/multicystic ameloblastoma (52.0) mostly affected Malays patients, whereas desmoplastic ameloblastoma (59.1) was prevalent in Chinese patients. Unicystic ameloblastoma (56.8) and solid/multicystic ameloblastoma (47.1) occurred predominantly in the body and posterior mandible, whereas desmoplastic ameloblastoma (36.4) preferentially involved the anterior jaw segment. Most tumors presented as multilocular radiolucencies (36.8). Enucleation (n = 42/92, 45.7) was the treatment of choice. About 18 cases (13.3) presented with recurrence. Conclusions: Because ameloblastoma subsets differ in their biologic behavior, the present data are significant as baseline references for clinicians and pathologists. (c) 2012 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 70:608-615, 2012

      Item Type: Article
      Creators:
      1. Siar, C.H.
      2. Lau, S.H.
      3. Ng, K.H.
      Journal or Publication Title: Journal of Oral and Maxillofacial Surgery
      Additional Information: ISI Document Delivery No.: 908QN Times Cited: 0 Cited Reference Count: 30 Cited References: Adebiyi Kehinde E, 2006, Head Face Med, V2, P42, DOI 10.1186/1746-160X-2-42 Avelar Rafael Linard, 2008, Braz J Otorhinolaryngol, V74, P668 Eckardt AM, 2009, J CRANIO MAXILL SURG, V37, P36, DOI 10.1016/j.jcms.2008.07.009 Fernandes AM, 2005, J ORAL PATHOL MED, V34, P583, DOI 10.1111/j.1600-0714.2005.00357.x Gardner DG, 2005, WHO CLASSIFICATION T, P296 Gunawardhana KSND, 2010, J ORAL PATHOL MED, V39, P236, DOI 10.1111/j.1600-0714.2009.00850.x Hertog D, 2010, ORAL ONCOL, V46, P61, DOI 10.1016/j.oraloncology.2009.11.002 Hong J, 2007, INT J ORAL MAX SURG, V36, P283, DOI 10.1016/j.ijom.2006.11.003 Huang IY, 2007, ORAL SURG ORAL MED O, V104, P478, DOI 10.1016/j.tripleo.2007.01.033 Jing W, 2007, INT J ORAL MAX SURG, V36, P20, DOI 10.1016/j.ijom.2006.10.01 Lau SL, 2006, INT J ORAL MAX SURG, V35, P681, DOI 10.1016/j.ijom.2006.02.016 Ledesma-Montes C, 2007, ORAL DIS, V13, P303, DOI 10.1111/j.1601-0825.2006.01284.x Lu Y, 1998, ORAL SURG ORAL MED O, V86, P707, DOI 10.1016/S1079-2104(98)90208-6 Luo HY, 2009, ORAL ONCOL, V45, P706, DOI 10.1016/j.oraloncology.2008.11.001 Martins WD, 2004, ORAL SURG ORAL MED O, V98, P657, DOI 10.1016/j.tripleo.2004.04.020 NG KH, 1990, ORAL SURG ORAL MED O, V70, P210, DOI 10.1016/0030-4220(90)90121-8 NG KH, 1993, BRIT J ORAL MAX SURG, V31, P299, DOI 10.1016/0266-4356(93)90064-4 Okada H, 2007, J ORAL MAXIL SURG, V65, P875, DOI 10.1016/j.joms.2006.06.293 Olaitan AA, 1998, INT J ORAL MAX SURG, V27, P456 Olgac V, 2006, BRIT J ORAL MAX SURG, V44, P386, DOI 10.1016/j.bjoms.2005.07.002 Pindborg JJ, 1971, INT HISTOLOGICAL CLA Poon C. S. P., 1996, Hong Kong Medical Journal, V2, P172 REICHART PA, 1995, ORAL ONCOL, V31B, P86 Sammartino G, 2007, BRIT J ORAL MAX SURG, V45, P306, DOI 10.1016/j.bjoms.2006.08.023 SIAR CH, 1993, BRIT J ORAL MAX SURG, V31, P183, DOI 10.1016/0266-4356(93)90122-D SIAR CH, 1991, J LARYNGOL OTOL, V105, P971 Siar C. H., 1993, Annals Academy of Medicine Singapore, V22, P856 Siriam G, 2008, ORAL SURG ORAL MED O, V105, pe14 Tawfik MA, 2010, ORAL SURG ORAL MED O, V109, pE67, DOI 10.1016/j.tripleo.2009.09.003 Zhang J, 2010, BRIT J ORAL MAX SURG, V48, P549, DOI 10.1016/j.bjoms.2009.08.020 Siar, Chong Huat Lau, Shin Hin Ng, Kok Han University of MalayaRG083/09HTM The authors thank all clinical specialists at the Ministry of Health, Malaysia, Faculty of Dentistry, University of Malaya and private hospitals/clinics for their case contributions that made this project possible. This study was supported by a grant from the University of Malaya (RG083/09HTM). W b saunders co-elsevier inc Philadelphia
      Uncontrolled Keywords: Odontogenic-tumors chinese population follow-up sri-lanka recurrence
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 10 Jan 2013 08:21
      Last Modified: 10 Jan 2013 08:21
      URI: http://eprints.um.edu.my/id/eprint/4324

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