Biswas, Mohitosh and Sukasem, Chonlaphat and Khatun Kali, Most Sumaiya and Ibrahim, Baharudin (2021) Effects of the CYP2C19 LoF allele on major adverse cardiovascular events associated with clopidogrel in acute coronary syndrome patients undergoing percutaneous coronary intervention: A meta-analysis. Pharmacogenomics, 23 (3). 207 -220. ISSN 1462-2416, DOI https://doi.org/10.2217/pgs-2021-0098.
Full text not available from this repository.Abstract
The aggregated risk of major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS) patients inheriting CYP2C19 loss-of function (LoF) alleles who underwent percutaneous coronary intervention (PCI) and were treated with clopidogrel is controversial. In the current study, we searched the literature in different databases for eligible studies. The risk ratio (RR) was measured where p<0.05 was statistically significant. The ACS patients with either one or two CYP2C19 LoF alleles who underwent PCI, treated with clopidogrel were correlated with a significantly escalated risk of MACE compared with noncarriers (RR: 1.53, 95 CI: 1.39-1.69, p < 0.00001), driven by CV death (RR: 1.88, 95 CI: 1.18-3.01, p = 0.008), MI (RR: 1.67, 95 CI: 1.21-2.31, p = 0.002) and ST (RR: 1.90, 95 CI: 1.27-2.84, p = 0.002). Patients with two CYP2C19 LoF alleles were correlated with significantly greater risk of MACE compared with noncarriers (RR: 3.91, 95 CI: 2.78-5.50, p < 0.00001). Further analysis revealed that the risk of MACE was markedly significant in Asian patients (RR: 2.02, 95 CI: 1.67-2.44, p < 0.00001) and was comparatively low significance in western patients (RR: 1.35, 95 CI: 1.20-1.52, p < 0.00001). There was no significantly different bleeding events in patients with CYP2C19 LoF alleles compared with noncarriers (RR: 0.99, 95 CI: 0.85-1.15, p = 0.87). The ACS patients inheriting CYP2C19 LoF alleles, who underwent PCI and were treated with clopidogrel were correlated with significantly increased risk of MACE compared with noncarriers. © 2022 Future Medicine Ltd.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Acute Coronary Syndrome; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Loss of Function Mutation; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Clopidogrel; Cytochrome P450 2C19; Antithrombocytic agent; Clopidogrel; CYP2C19 protein |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Clinical Pharmacy and Pharmacy Practice |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Nov 2023 03:29 |
| Last Modified: | 21 Nov 2023 03:29 |
| URI: | http://eprints.um.edu.my/id/eprint/43211 |
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