Sodium–glucose cotransporter 2 inhibitor-induced euglycemic diabetic ketoacidosis in a patient with coronavirus disease 2019: a case report

Yii, Edwin Sze Sian and Azli, Athirah Wan and Sitaram, Premela Naidu (2022) Sodium–glucose cotransporter 2 inhibitor-induced euglycemic diabetic ketoacidosis in a patient with coronavirus disease 2019: a case report. Journal of Medical Case Reports, 16 (1). p. 17. ISSN 1752-1947, DOI https://doi.org/10.1186/s13256-021-03232-3.

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Abstract

Background: Sodium–glucose cotransporter 2 inhibitors are among the new-generation oral antihyperglycemic agents that have been used in the treatment of type 2 diabetes mellitus. With the recent coronavirus disease 2019 pandemic and rise of cases in the third wave, diagnosis of life-threatening euglycemic diabetic ketoacidosis may easily be overlooked or missed. Case presentation: We present the case of a 37-year-old Malay gentleman with underlying type 2 diabetes mellitus on empagliflozin, who presented to our hospital with symptomatic coronavirus disease 2019 infection and diabetic ketoacidosis. He developed severe rebound euglycemic diabetic ketoacidosis due to the continuous usage of empagliflozin for glycemic control alongside intravenous insulin. Conclusions: Physicians should have a high index of suspicion in diagnosing and managing euglycemic diabetic ketoacidosis, including withholding treatment of sodium–glucose cotransporter 2 inhibitors during the acute management of diabetic ketoacidosis. © 2022, The Author(s).

Item Type: Article
Funders: None
Uncontrolled Keywords: Adult; COVID-19; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Glucose; Humans; Male; SARS-CoV-2; Sodium
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Anaesthesiology Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Sep 2023 12:40
Last Modified: 28 Sep 2023 12:40
URI: http://eprints.um.edu.my/id/eprint/43189

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