Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
Romanos, G.E.; Toh, C.G.; Siar, C.H.; Wicht, H.; Yacoob, H.; Nentwig, G.H. (2003) Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey. Journal of Periodontology, 74 (10). pp. 1483-1490. ISSN 0022-3492
Background: Bone healing around endosseous dental implants is associated with peri-implant loading conditions. Therefore, the aim of this study was to evaluate histomorphometrically the bone response around unloaded, delayed, and immediately loaded implants with a progressive thread design that were placed in the posterior regions of the lower jaw in monkeys. Methods: Nine adult monkeys (Macaca fascicularis) were used in this study. After extraction of the second premolars and first and second molars in the mandible, the bone was allowed to heal for a period of 3 months. Forty-eight 8 mm long implants with a diameter of 3.5 mm were placed according to the following protocol. In two of the monkeys, six implants were placed and left to heal submerged for 3 months (group A). In seven monkeys, 21 implants were placed in one side of the mandible and loaded after 3 months of submerged healing (group B). The group B implants were loaded with temporary resin bridges at the same time as another 21 implants that were loaded immediately (group C) after placement in the contralateral side of the mandibles of the same monkeys. The occlusion of group B and C implants was checked for optimal relationship of the resin bridges that were replaced 1 month later with metal bridges and loaded for an additional 2 months. The group A animals were sacrificed after 3 months of submerged healing without loading; group B and C animals were sacrificed after 3 months of implant loading. Specimens were examined histologically and histomorphometrically. Results: All implants osseointegrated without presenting any gap in the metal-bone interface. Compact cortical bone was found in contact with the implant surfaces. Group A implants demonstrated in the interface cancellous bone with loose connective tissue. Group B and C in-plants showed a thick cortical plate with extensive bone trabeculae formation. There was a significant difference in bone-to-implant contact (BIC) between the various loading conditions. No significant difference (P<0.05) was found between groups B and C. There was an increased area of bone (BA) within the threads as well as around the apices of group B and C implants. Conclusions: Implant loading might have stimulated increased bone formation and thus may be a key factor in influencing positive osseointegration. In addition, immediately loaded implants may osseointegrate in a similar manner as delayed loaded implants.
|Item Type: ||Article|
- Romanos, G.E.
- Toh, C.G.
- Siar, C.H.
- Wicht, H.
- Yacoob, H.
- Nentwig, G.H.
|Journal or Publication Title: ||Journal of Periodontology|
|Additional Information: ||ISI Document Delivery No.: 754KN Times Cited: 32 Cited Reference Count: 33 Cited References: Albrektsson T, 1986, Int J Oral Maxillofac Implants, V1, P11 Bloebaum R D, 1992, J Arthroplasty, V7, P483, DOI 10.1016/S0883-5403(05)80222-0 BRANEMARK PI, 1983, J PROSTHET DENT, V50, P399, DOI 10.1016/S0022-3913(83)80101-2 Buser D, 1998, INT J ORAL MAX IMPL, V13, P611 Buser D A, 1988, Int J Oral Maxillofac Implants, V3, P173 Chappard D, 1999, INT J ORAL MAX IMPL, V14, P189 Chappard D, 1996, J BIOMED MATER RES, V32, P175, DOI 10.1002/(SICI)1097-4636(199610)32:2<175::AID-JBM4>3.0.CO;2-Q DALEN N, 1974, ACTA ORTHOP SCAND, V45, P170, DOI 10.3109/17453677408989136 Davies JE, 1996, ANAT REC, V245, P426, DOI 10.1002/(SICI)1097-0185(199606)245:2<426::AID-AR21>3.0.CO;2-Q DELANGE GL, 1989, BIOMATERIALS, V10, P121, DOI 10.1016/0142-9612(89)90044-6 DONATH K, 1982, J ORAL PATHOL MED, V11, P318, DOI 10.1111/j.1600-0714.1982.tb00172.x FROST HM, 1990, ANAT REC, V226, P403, DOI 10.1002/ar.1092260402 Gotfredsen K, 1991, CLIN ORAL IMPLAN RES, V2, P30, DOI 10.1034/j.1600-0501.1991.020104.x GRANHED H, 1987, SPINE, V12, P146, DOI 10.1097/00007632-198703000-00010 HANSSON HA, 1983, J PROSTHET DENT, V50, P108, DOI 10.1016/0022-3913(83)90175-0 KOHRI M, 1990, J ORAL MAXIL SURG, V48, P1265, DOI 10.1016/0278-2391(90)90480-P KROLNER B, 1982, CLIN PHYSIOL, V2, P147, DOI 10.1111/j.1475-097X.1982.tb00017.x LANYON LE, 1984, J BIOMECH, V17, P897, DOI 10.1016/0021-9290(84)90003-4 NAKABAYASHI Y, 1987, Journal of the Japanese Orthopaedic Association, V61, P1429 Nentwig GH, 1993, IMPLANTOLOGIE, V3, P225 NILSSON BE, 1971, CLIN ORTHOP RELAT R, P179 Oda J, 1996, BIOMECHANICS FUNCTIO, P123 PERETTIRENUCCI R, 1991, J NEUROSCI RES, V28, P583, DOI 10.1002/jnr.490280416 RUBIN CT, 1990, J BIOMECH, V23, P43, DOI 10.1016/0021-9290(90)90040-A Sakai K, 1990, ORTHOP BIOMECH, V12, P99 SALAMA H, 1995, INT J PERIODONT REST, V15, P345 SAMMARCO GJ, 1971, J BIOMECH, V4, P113, DOI 10.1016/0021-9290(71)90021-2 SAVILLE PD, 1966, AM J PHYS ANTHROPOL, V25, P35, DOI 10.1002/ajpa.1330250105 STRUNTZ V, 1983, FORTSCHRITTE KIEFER, V28, P47 Takuma M, 1987, J Osaka Univ Dent Sch, V27, P111 Tarnow DP, 1997, INT J ORAL MAX IMPL, V12, P319 WOLFF J, 1892, LAW TRANSFORMATION B, pS1 WONG M, 1995, J BIOMED MATER RES, V29, P1567, DOI 10.1002/jbm.820291213 Romanos, GE Toh, CG Siar, CH Wicht, H Yacoob, H Nentwig, GH Amer acad periodontology Chicago|
|Uncontrolled Keywords: ||Animal studies bone and bones/anatomy and histology dental implants endosseous osseointegration osteogenesis physical-activity osseointegration hydroxyapatite density weight tissue mass|
|Subjects: ||R Medicine > RK Dentistry|
|Divisions: ||Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology|
|Depositing User: ||Ms Nursyafiqah Abd Malek|
|Date Deposited: ||09 Jan 2013 10:39|
|Last Modified: ||09 Jan 2013 10:39|
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