Rivera, R.S. and Nagatsuka, H. and Gunduz, M. and Cengiz, B. and Gunduz, E. and Siar, C.H. and Tsujigiwa, H. and Tamamura, R. and Han, K.N. and Nagai, N. (2008) C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Archiv, 452 (1). pp. 27-32. ISSN 0945-6317, DOI https://doi.org/10.1007/s00428-007-0524-2.
![[img]](http://eprints.um.edu.my/style/images/fileicons/application_pdf.png)
|
PDF
C-kit_protein_expression_correlated_with_activating_mutations_in_KIT_gene_in_oral_mucosal_melanoma.pdf Download (28kB) |
Abstract
C-kit is a trans-membrane receptor tyrosine kinase (RTK) encoded by the proto-oncogene KIT located at 4q11-12. Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. C-kit also participates in melanocyte development; hence, its involvement in oral mucosal melanoma (OMM) tumorigenesis was investigated. Immunohistochemistry and mutation analysis were performed using 18 cases of human primary OMM. Results revealed 16 cases positive to c-kit protein. Atypical melanocytes expressed c-kit. All in situ components expressed c-kit, but only four cases exhibited intense expression in the invasive component. Missense mutations were observed in four cases, and two of those correlated with increased protein expression. C-kit expression in atypical melanocytes suggests the role of c-kit in the early stage of OMM tumorigenesis. C-kit protein expression correlated with activating mutations indicating the pertinent role of the proto-oncogene KIT in the tumorigenesis of OMM.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | ISI Document Delivery No.: 243XP Times Cited: 55 Cited Reference Count: 40 Cited References: Alexeev V, 2006, J INVEST DERMATOL, V126, P1102, DOI 10.1038/sj.jid.5700125 Alexis JB, 2005, MELANOMA RES, V15, P283, DOI 10.1097/00008390-200508000-00008 All-Ericsson C, 2004, INVEST OPHTH VIS SCI, V45, P2075, DOI 10.1167/iovs.03-1196 Andersson J, 2006, GASTROENTEROLOGY, V130, P1573, DOI 10.1053/j.gastro.2006.01.043 Barker BF, 1997, ORAL SURG ORAL MED O, V83, P672, DOI 10.1016/S1079-2104(97)90318-8 Becker JC, 2007, J CLIN ONCOL, V25, pE9, DOI 10.1200/JCO.2006.08.9664 Corless CL, 2002, AM J PATHOL, V160, P1567, DOI 10.1016/S0002-9440(10)61103-0 Curtin JA, 2006, J CLIN ONCOL, V24, P4340, DOI 10.1200/JCO.2006.06.2984 Daum O, 2007, ANN DIAGN PATHOL, V11, P27, DOI 10.1016/j.aiindiagpath.2006.10.002 Do I, 2007, PATHOL RES PRACT, V203, P127, DOI 10.1016/j.prp.2006.12.005 Fiorentini G, 2003, J EXP CLIN CANC RES, V22, P17 Flaherty KT, 2006, CLIN CANCER RES, V12, p2366S, DOI 10.1158/1078-0432.CCR-05-2505 Hicks MJ, 2000, ORAL ONCOL, V36, P152, DOI 10.1016/S1368-8375(99)00085-8 Hirota S, 2003, GASTROENTEROLOGY, V125, P660, DOI 10.1016/S001-5085(03)01046-1 Isozaki K, 2000, AM J PATHOL, V157, P1581, DOI 10.1016/S0002-9440(10)64795-5 Ivan D, 2006, J CUTAN PATHOL, V33, P280, DOI 10.1111/j.0303-6987.2006.00432.x Jin TF, 2006, WORLD J GASTROENTERO, V12, P703 Kang DY, 2007, AM J SURG PATHOL, V31, P224, DOI 10.1097/01.pas.0000213318.66800.94 Kinoshita K, 2003, J GASTROEN HEPATOL, V18, P147, DOI 10.1046/j.1440-1746.2003.02911.x Lefevre G, 2004, J BIOL CHEM, V279, P31769, DOI 10.1074/jbc.M403907200 Lennartsson J, 1999, ONCOGENE, V18, P5546, DOI 10.1038/sj.onc.1202929 Leslie MC, 2005, J CELL BIOCHEM, V94, P25, DOI 10.1002/jcb.20296 Lin SC, 2006, J GASTROEN HEPATOL, V21, P1604, DOI 10.1111/j.1440-1746.2006.04322.x Litz J, 2006, MOL CANCER THER, V5, P1415, DOI 10.1158/1535-7163.MCT-05-0503 Litz J, 2004, LUNG CANCER-J IASLC, V46, P283, DOI 10.1016/j.lungcan.2004.05.005 Lux ML, 2000, AM J PATHOL, V156, P791, DOI 10.1016/S0002-9440(10)64946-2 Montone KT, 1997, MODERN PATHOL, V10, P939 Nagatsuka H, 2005, VIRCHOWS ARCH, V447, P710, DOI 10.1007/s00428-005-0016-1 NATALI PG, 1992, INT J CANCER, V52, P197, DOI 10.1002/ijc.2910520207 Ohashi A, 1996, MELANOMA RES, V6, P25, DOI 10.1097/00008390-199602000-00004 Pache M, 2003, VIRCHOWS ARCH, V443, P741, DOI 10.1007/s00428-003-0883-2 Puputti M, 2006, MOL CANCER RES, V4, P927, DOI 10.1158/1541-7786.MCR-06-0085 Rapidis AD, 2003, J ORAL MAXIL SURG, V61, P1132, DOI 10.1016/S0278-2391(03)00670-0 Shen SS, 2003, J CUTAN PATHOL, V30, P539, DOI 10.1034/j.1600-0560.2003.00090.x Stefanou D, 2004, INT J SURG PATHOL, V12, P133, DOI 10.1177/106689690401200206 Ugurel S, 2005, BRIT J CANCER, V92, P1398, DOI 10.1038/sj.bjc.6602529 Wardelmann E, 2003, INT J CANCER, V106, P887, DOI 10.1002/ijc.11323 Willmore C, 2004, AM J CLIN PATHOL, V122, P206, DOI 10.1309/4E6UYBY62N2FCA6N Willmore-Payne C, 2005, HUM PATHOL, V36, P486, DOI 10.1016/j.humpath.2005.03.015 Wyman K, 2006, CANCER, V106, P2005, DOI 10.1002/cncr.21834 Rivera, Rosario S. Nagatsuka, Hitoshi Gunduz, Mehmet Cengiz, Beyhan Gunduz, Esra Siar, Chong Huat Tsujigiwa, Hidetsugu Tamamura, Ryo Han, Kok Ng Nagai, Noriyuki Springer New york |
| Uncontrolled Keywords: | Oral mucosal melanoma C-kit mutation immunohistochemistry gastrointestinal stromal tumors endothelial growth-factor amplicon melting analysis malignant-melanoma imatinib mesylate metastatic melanoma melanocytic lesions clinical-efficacy cd-117 expression kinase domain |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology |
| Depositing User: | Ms Nursyafiqah Abd Malek |
| Date Deposited: | 09 Jan 2013 01:19 |
| Last Modified: | 09 Jan 2013 01:19 |
| URI: | http://eprints.um.edu.my/id/eprint/4310 |
Actions (login required)
 |
View Item |
