C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma

Rivera, R.S.; Nagatsuka, H.; Gunduz, M.; Cengiz, B.; Gunduz, E.; Siar, C.H.; Tsujigiwa, H.; Tamamura, R.; Han, K.N.; Nagai, N. (2008) C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Archiv, 452 (1). pp. 27-32. ISSN 0945-6317

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    Abstract

    C-kit is a trans-membrane receptor tyrosine kinase (RTK) encoded by the proto-oncogene KIT located at 4q11-12. Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. C-kit also participates in melanocyte development; hence, its involvement in oral mucosal melanoma (OMM) tumorigenesis was investigated. Immunohistochemistry and mutation analysis were performed using 18 cases of human primary OMM. Results revealed 16 cases positive to c-kit protein. Atypical melanocytes expressed c-kit. All in situ components expressed c-kit, but only four cases exhibited intense expression in the invasive component. Missense mutations were observed in four cases, and two of those correlated with increased protein expression. C-kit expression in atypical melanocytes suggests the role of c-kit in the early stage of OMM tumorigenesis. C-kit protein expression correlated with activating mutations indicating the pertinent role of the proto-oncogene KIT in the tumorigenesis of OMM.

    Item Type: Article
    Creators:
    1. Rivera, R.S.
    2. Nagatsuka, H.
    3. Gunduz, M.
    4. Cengiz, B.
    5. Gunduz, E.
    6. Siar, C.H.
    7. Tsujigiwa, H.
    8. Tamamura, R.
    9. Han, K.N.
    10. Nagai, N.
    Journal or Publication Title: Virchows Archiv
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    Uncontrolled Keywords: Oral mucosal melanoma C-kit mutation immunohistochemistry gastrointestinal stromal tumors endothelial growth-factor amplicon melting analysis malignant-melanoma imatinib mesylate metastatic melanoma melanocytic lesions clinical-efficacy cd-117 expression kinase domain
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Ms Nursyafiqah Abd Malek
    Date Deposited: 09 Jan 2013 09:19
    Last Modified: 09 Jan 2013 09:19
    URI: http://eprints.um.edu.my/id/eprint/4310

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