Fung, Shin-Yee and Yap, Hui-Yeng Yeannie and Ng, Szu-Ting and Tan, Chon-Seng (2022) In vitro inhibition of melanin formation and enhancement of collagen production by a mushroom sclerotial water extract from the tiger milk mushroom, lignosus rhinocerus (agaricomycetes), with no skin and eye irritation. International Journal of Medicinal Mushrooms, 24 (5). pp. 19-32. ISSN 1521-9437,
Full text not available from this repository.Abstract
Lignosus rhinocerus has bioactive properties, such as anti-inflammatory, antioxidant, antiglycation, and immunomodulatory effects, that are beneficial to the skin. Gas chromatography-mass spectrometry analysis revealed the presence of cosmeceutical compounds, including linoleates, ascorbic acid dipahnitate, and all-trans-squalene, in the mushroom sclerotium. We further investigated the depigmentation and antiaging activities of L. rhinoceros cultivar TM02 sclerotia cold water extract (TM-CWE). TM-C WE at 10% (v/v) inhibited melanin production at the intro- and extracellular levels of B16-F1 melanoma cells (50.6-53.3%) and downregulated microplahalinia-associated transcription factor, the key protein for melanogenic enzyme expression, at the intracellular level (44.5 +/- 2.6%). The extract also promoted human procollagen type 1 production in HaCat cells by 51.30 +/- 2.87% at 12.5% (v/v). Irritation tests using three-dimensional eye and skin models further indicated that TM-CWE is a nonirritant with > 75% viability. Therefore, L. rhinoceros TM02 demonstrated the capacity to be a beneficial ingredient for skin care application.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant FRGS [Grant No: 2019-1 (FRGS/1/2019/SKK08/MAHSA/03/1)], SIRIM Fraunhofer Programme - Enhancement of Competitiveness and Market Access of SMEs (ECMAS) under the SIIMF Fund [Grant No: BIO 238/5/1] |
| Uncontrolled Keywords: | Lignosus rhinoceros; Tiger milk mushroom; Pigmentation; Human procollagen type 1; Nonirritant; Melanin; Cosmeceutical compounds; Medicinal mushrooms |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QL Zoology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Aug 2023 08:23 |
| Last Modified: | 29 Aug 2023 08:23 |
| URI: | http://eprints.um.edu.my/id/eprint/43088 |
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