Choy, Seow Huey and Nyanatay, Selina Ann and Sothilingam, Selvalingam and Malek, Rohan and Sathiyananthan, J. R. and Toh, Charng Chee and Sundram, Murali and Yusoff, Noor Ashani Md and Nagappan, Poongkodi and Kamaruzaman, Shakirin and Yeoh, Wei Sien and Ong, Teng Aik and Lim, Jasmine (2022) Cardiovascular risk factors, ethnicity and infection stone are independent factors associated with reduced renal function in renal stone formers. PLoS ONE, 17 (4). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0265510.
Full text not available from this repository.Abstract
Background Recent evidence suggested the link between nephrolithiasis and renal function impairment. We aimed to determine the renal function profile and potential factors associated with reduced renal function amongst renal stone formers in multi-ethnic Asians. Methods We conducted a cross-sectional study involving patients undergoing percutaneous nephrolithotomy between May 2015 and December 2019. Reduced renal function was defined as having estimated glomerular filtration rate < 60 ml/min per 1.73 m(2). Renal stone samples were collected and quantified using infrared spectroscopy. Potential factors associated with reduced renal function including age, ethnicity, educational level, history of diabetes, hypertension, gout, hydronephrosis, serum uric acid level, and type of renal stone were evaluated using univariable and multivariable analyses. Results A total of 1162 patients from a multi-ethnic population (Malays 67%, Chinese 19%, Indians 13% and indigenous people 1%) with median age of 57 years (Interquartile range 48-64) were enrolled in the study. Almost a third of patients were found with reduced renal function. Multivariable analysis showed that the odds of having reduced renal function increased with age, ethnicity, lower educational level, history of diabetes, hypertension, gout, bilateral hydronephrosis, elevated serum uric acid level and infection stone. Conclusions Reduced renal function varies between ethnicities and all age groups of renal stone formers. In addition to age and ethnicity, cardiovascular risk factors including diabetes hypertension may also need to be taken into account in managing stone patients with reduced renal function.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya (UM) [Grant No: RG363/15AFR], Cook Medical Education Fund, Avro Abadi Sdn Bhd |
| Uncontrolled Keywords: | Chronic kidney-disease; Metabolic syndrome; Urinary stones |
| Subjects: | Q Science > Q Science (General) R Medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Aug 2023 08:34 |
| Last Modified: | 29 Aug 2023 08:34 |
| URI: | http://eprints.um.edu.my/id/eprint/43086 |
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