Abu Bakar, Nurlizah and Lau, Benjamin Yii Chung and Smykla, Jerzy and Karsani, Saiful Anuar and Alias, Siti Aisyah (2022) Protein homeostasis, regulation of energy production and activation of DNA damage-repair pathways are involved in the heat stress response of Pseudogymnoascus spp. Environmental Microbiology, 24 (4). pp. 1849-1864. DOI https://doi.org/10.1111/1462-2920.15776.
Full text not available from this repository.Abstract
Proteome changes can be used as an instrument to measure the effects of climate change, predict the possible future state of an ecosystem and the direction in which is headed. In this study, proteomic and gene ontology functional enrichment analysis of six Pseudogymnoascus spp. isolated from various global biogeographical regions were carried out to determine their response to heat stress. In total, 2122 proteins were identified with high confidence. Comparative quantitative analysis showed that changes in proteome profiles varied greatly between isolates from different biogeographical regions. Although the identities of the proteins that changed varied between the different regions, the functions they governed were similar. Gene ontology analysis showed enrichment of proteins involved in multiple protective mechanisms, including the modulation of protein homeostasis, regulation of energy production and activation of DNA damage and repair pathways. Our proteomic analysis did not show any clear relationship between protein changes and the strains' biogeographical origins.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Higher Education (MOHE) [Grant No: IOES-2014G], Universiti Malaya Research Programme (UMRP) [Grant No: RP026A-18SUS], Majlis Amanah Rakyat Malaysia (MARA Scholarship Programme) |
| Uncontrolled Keywords: | Sample preparation; Shock response; Growth; Fungi; Evolution; Climate change; Energy production; Protein homeostasis |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Science > Institute of Biological Sciences Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Sep 2023 03:29 |
| Last Modified: | 06 Sep 2023 03:29 |
| URI: | http://eprints.um.edu.my/id/eprint/43064 |
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