Tarmizi, Nor Athirah Kamaliah Ahmad and Kushairi, Naufal and Phan, Chia Wei and Sabaratnam, Vikineswary and Kuppusamy Naidu, Murali and David, Pamela (2022) beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet. Journal of Medicinal Food, 25 (3). pp. 230-238. ISSN 1096-620X, DOI https://doi.org/10.1089/jmf.2021.K.0121.
Full text not available from this repository.Abstract
Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of beta-glucan-rich Pleurotus pulmonarius (beta gPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development. Female ICR mice were fed with normal diet (ND), ND with beta gPp, high-fat diet (HFD), or HFD with beta gPp for 3 months followed by behavioral test and mating. Immunohistochemistry for the expression of neuronal nuclear protein (NeuN) and ionized calcium binding adaptor molecule-1 (Iba-1) in the hippocampus was carried out. beta gPp significantly enhanced short-term object recognition memory in HFD-fed mice. beta gPp also ameliorated the histological alterations and neuronal loss and increased Iba-1-positive microglia in the hippocampus regions of HFD-fed mice and their male offspring. These findings demonstrated that beta gPp supplementation attenuated the effects of HFD on object recognition memory and the alterations on the hippocampal regions of maternal mice and their male offspring.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya under the Research University Grant, RU Grant [Grant No: RF010C-2018], Ministry of Higher Education, Malaysia, for the Fundamental Research Grant Scheme, FRGS [Grant No: FP008-2017A], Ministry of Energy, Science, Technology, Environment and Climate Change (MESTECC), Malaysia [Grant No: FRGS/1/2017/SKK08/UM/01/12] |
| Uncontrolled Keywords: | Inflammation; Microglia; Neuron; Neuroprotective; Obesity; Offspring |
| Subjects: | Q Science > QD Chemistry R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine Faculty of Science > Institute of Biological Sciences Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Sep 2023 03:38 |
| Last Modified: | 27 Nov 2024 02:15 |
| URI: | http://eprints.um.edu.my/id/eprint/43063 |
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