Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions

Ram, S.; Siar, C.H. (2005) Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. International Journal of Oral and Maxillofacial Surgery, 34 (5). pp. 521-527. ISSN 0901-5027

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      Abstract

      Chemiluminescence was evaluated as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions (PMELs) by comparing it against 1 tolonium chloride mouth rinse. Forty-six clinically identified lesions 14 primary squamous cell carcinoma (SCC), 26 PMELs and 6 benign lesions and five cases of normal oral mucosa from 40 subjects (inclusive of 10 previously treated SCC cases) were examined with a commercial chemiluminescent kit (Vizilite (R)) and tolonium chloride. Biopsy and histological verification of 31 lesions disclosed 14 SCC (45.2%), 10 epithelial dysplasias (32.3%), 5 lichen planus (16.1%) and 2 benign lesions (6.4%). For the remaining 15 lesions, a biopsy was not performed owing to patient's lack of consent or ill-health. The five cases of normal oral mucosa which tested negative for both tools were also not biopsied for ethical reasons. Sensitivity for Vizilite (R) and tolonium chloride was 100% and 70.3%, respectively; and specificity was 14.2% for Vizilite (R) and 25% for tolonium chloride. Their accuracy was 80.6% and 64.5%, respectively. Current findings suggest that chemiluminescence is a more reliable diagnostic tool than tolonium chloride in the detection of oral cancer and PMELs, and for follow-up of patients treated for the same.

      Item Type: Article
      Creators:
      1. Ram, S.
      2. Siar, C.H.
      Journal or Publication Title: International Journal of Oral and Maxillofacial Surgery
      Additional Information: ISI Document Delivery No.: 940XI Times Cited: 36 Cited Reference Count: 25 Cited References: CARLSON R, 2000, AUST J CHEM ED, V14, P51 CRAIG G, 1998, BDA OCCASIONAL PAPER, V5, P5 Ephros H, 1999, ORAL SURG ORAL MED O, V87, P526, DOI 10.1016/S1079-2104(99)70148-4 Epstein JB, 1997, ORAL SURG ORAL MED O, V83, P537, DOI 10.1016/S1079-2104(97)90117-7 HERLIN P, 1983, ENDOSCOPY, V15, P4, DOI 10.1055/s-2007-1018595 Horowitz AM, 2000, J AM DENT ASSOC, V131, P453 JOHNSON NW, 1999, ORAL CANC, P24 Klug C, 2002, INT J ORAL MAX SURG, V31, P664, DOI 10.1054/ijom.2002.0301 LONKY NM, 1995, J REPROD MED, V40, P530 MANN W, 1993, INT J GYNECOL OBSTET, V43, P289, DOI 10.1016/0020-7292(93)90518-2 Manuel S, 2003, INT J ORAL MAX SURG, V32, P167, DOI 10.1054/ijom.2002.0271 Martin IC, 1998, ORAL SURG ORAL MED O, V85, P444, DOI 10.1016/S1079-2104(98)90071-3 MASHBERG A, 1983, J AM DENT ASSOC, V106, P319 MASHBERG A, 1981, JAMA-J AM MED ASSOC, V245, P2408, DOI 10.1001/jama.245.23.2408 Murdoch-Kinch C A, 1999, J Calif Dent Assoc, V27, P773 NIEBEL HH, 1964, J AM DENT ASSOC, V68, P801 Parham GP, 2003, AM J OBSTET GYNECOL, V188, pS13, DOI 10.1067/mob.2003.234 Porter SR, 1998, BRIT DENT J, V185, P72, DOI 10.1038/sj.bdj.4809732 ROSENBERG D, 1989, ORAL SURG ORAL MED O, V67, P621, DOI 10.1016/0030-4220(89)90286-7 SABES WR, 1972, CANCER, V29, P1584, DOI 10.1002/1097-0142(197206)29:6<1584::AID-CNCR2820290624>3.0.CO;2-9 SHEDD DP, 1967, ARCH SURG-CHICAGO, V95, P16 SIGURDSO.A, 1973, ACTA OTO-LARYNGOL, V75, P308, DOI 10.3109/00016487309139725 STRONG MC, 1968, ARCH OTOLARYNGOL, V87, P101 Thomson PJ, 2002, INT J ORAL MAX SURG, V31, P262, DOI 10.1054/ijom.2002.0220 Weijers M, 2004, INT J ORAL MAX SURG, V33, P146, DOI 10.1054/ijom.2002.0469 Ram, S Siar, CH Churchill livingstone Edinburgh
      Uncontrolled Keywords: Chemiluminescence Vizilite((R)) tolonium chloride oral cancer PMEL squamous-cell carcinoma toluidine blue tolonium chloride dysplasia tongue rinse risk
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 09 Jan 2013 09:18
      Last Modified: 09 Jan 2013 09:18
      URI: http://eprints.um.edu.my/id/eprint/4306

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