Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells

Nagatsuka, H.; Han, P.P.; Tsujigiwa, H.; Siar, C.H.; Gunduz, M.; Sugahara, T.; Sasaki, A.; Nakajima, M.; Naomoto, Y.; Nagai, N. (2005) Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells. Oral Oncology, 41 (5). pp. 542-548. ISSN 1368-8375

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      Abstract

      Ametoblastoma is the most common odontogenic neoplasm, particularized by its local invasiveness. Heparanase is the endo-glucuronidase enzyme that specifically cleaves heparan sulfate, the important modulator of extracellular matrix, and related to invasion of tumor cells. In this study, we addressed to show the gene expression and localization of heparanase in ametoblastoma. Immunohistochemistry and in situ hybridization of heparanase were carried out in 23 ameloblastomas. Strong expression of heparanase at both mRNA and protein levels was detected in all ameloblastomas studied. Small tumor nests and budding epithelial. branches showed stronger staining pattern and the stromal tissues at the immediate vicinity of the tumor nests with strong heparanase expression were loose and edematous. Cystic areas and squamous metaplastic areas of the tumor showed intense staining with heparanase antibody proposing the implication of heparanase in these processes. These results suggest the possible contribution of heparanase in the local invasiveness and secondary morphologic changes of ameloblastoma. (c) 2005 Elsevier Ltd. All rights reserved.

      Item Type: Article
      Creators:
      1. Nagatsuka, H.
      2. Han, P.P.
      3. Tsujigiwa, H.
      4. Siar, C.H.
      5. Gunduz, M.
      6. Sugahara, T.
      7. Sasaki, A.
      8. Nakajima, M.
      9. Naomoto, Y.
      10. Nagai, N.
      Journal or Publication Title: Oral Oncology
      Additional Information: ISI Document Delivery No.: 931FN Times Cited: 11 Cited Reference Count: 29 Cited References: BAME KJ, 2001, GLYCOBIOLOGY, V11, pE91 Bernfield M, 1999, ANNU REV BIOCHEM, V68, P729, DOI 10.1146/annurev.biochem.68.1.729 Carey DJ, 1997, BIOCHEM J, V327, P1 El-Assal ON, 2001, CLIN CANCER RES, V7, P1299 Endo K, 2001, ANTICANCER RES, V21, P3365 Erickson AC, 2000, J HISTOCHEM CYTOCHEM, V48, P1291 Friedmann Y, 2000, AM J PATHOL, V157, P1167, DOI 10.1016/S0002-9440(10)64632-9 Gohji K, 2001, J UROLOGY, V166, P1286, DOI 10.1016/S0022-5347(05)65754-0 Ida-Yonemochi H, 2002, VIRCHOWS ARCH, V441, P165, DOI 10.1007/s00428-001-0556-y JIN L, 1990, INT J CANCER, V45, P1088, DOI 10.1002/ijc.2910450618 Koliopanos A, 2001, CANCER RES, V61, P4655 KRAMER IR, 1992, CANCER, V70, P2894 Kramer IRH, 1992, HISTOLOGICAL TYPING, P11 Mikami S, 2001, JPN J CANCER RES, V92, P1062 NAGATSUKA H, HEPARANASE MRNA GENE Nagatsuka H, 2002, VIRCHOWS ARCH, V441, P392, DOI 10.1007/s00428-002-0658-1 NAKAJIMA M, 1988, J CELL BIOCHEM, V36, P157, DOI 10.1002/jcb.240360207 Nakano K, 2002, J ORAL PATHOL MED, V31, P494, DOI 10.1034/j.1600-0714.2002.00162.x Ohkawa T, 2004, LAB INVEST, V84, P1289, DOI 10.1038/labinvest.3700159 Parish C.R., 2001, BIOCHIM BIOPHYS ACTA, V1471, P99 Pinheiro JJV, 2004, HISTOPATHOLOGY, V45, P65, DOI 10.1111/j.1365-2559.2004.01902.x Reichart P A, 1995, Eur J Cancer B Oral Oncol, V31B, P86, DOI 10.1016/0964-1955(94)00037-5 Reiland J, 2004, J BIOL CHEM, V279, P8047, DOI 10.1074/jbc.M304872200 SAUK JJ, 1985, J ORAL PATHOL MED, V14, P307, DOI 10.1111/j.1600-0714.1985.tb00498.x Takaoka M, 2003, LAB INVEST, V83, P613, DOI 10.1097/01.LAB.0000067482.84946.BD Vlodavsky I, 1996, CANCER METAST REV, V15, P177, DOI 10.1007/BF00437470 Vlodavsky I, 2001, J CLIN INVEST, V108, P341, DOI 10.1172/JCI13662 Vlodavsky I, 2002, SEMIN CANCER BIOL, V12, P121, DOI 10.1006/scbi.2001.0420 Yu WH, 2000, J BIOL CHEM, V275, P4183, DOI 10.1074/jbc.275.6.4183 Nagatsuka, H Han, PP Tsujigiwa, H Siar, CH Gunduz, M Sugahara, T Sasaki, A Nakajima, M Naomoto, Y Nagai, N Elsevier science bv Amsterdam
      Uncontrolled Keywords: Ameloblastoma heparanase heparan sulfate local invasion fibroblast-growth-factor sulfate proteoglycans basement-membranes cancer metastasis localization involvement angiogenesis syndecan-1 prognosis molecules
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 09 Jan 2013 10:39
      Last Modified: 09 Jan 2013 10:39
      URI: http://eprints.um.edu.my/id/eprint/4291

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