Angioarchitecture of primary oral malignant melanomas

Lee, Y.J. and Nagai, N. and Siar, C.H. and Nakano, K. and Nagatsuka, H. and Tsujigiwa, H. and Roan, C.H. and Gunduz, M. (2002) Angioarchitecture of primary oral malignant melanomas. Journal of Histochemistry & Cytochemistry, 50 (11). pp. 1555-1562. ISSN 0022-1554


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Angiogenesis is an essential process in the progression of malignant tumors. However, little is known of the angioarchitecture in primary oral malignant melanoma. We sought to determine this by the use of periodic acid-Schiff (PAS) stain, endothelial markers (CD34, CD105) and laminin, and by transmission electron microscopy in two cases. The results demonstrated that endothelium-lined vessels dominated the tumor microvasculature and these stained positively for PAS, laminin, and endothelial markers. Mosaic and tumor-lined vessels were infrequently encountered. Most PAS-positive patterned networks and loops ultrastructurally represented intratumor microhemorrhages that probably arose secondary to tumor vessel leakiness. Vascular channels of the vasculogenic mimicry type were rare. They stained for laminin but not for endothelial markers.

Item Type: Article
Additional Information: ISI Document Delivery No.: 626NL Times Cited: 14 Cited Reference Count: 47 Cited References: ANDERSEN LJ, 1992, J OTOLARYNGOL, V21, P180 Bissell MJ, 1999, AM J PATHOL, V155, P675, DOI 10.1016/S0002-9440(10)65164-4 Carmeliet P, 2000, NAT MED, V6, P389, DOI 10.1038/74651 Chang YS, 2000, P NATL ACAD SCI USA, V97, P14608, DOI 10.1073/pnas.97.26.14608 Chiu NT, 1996, ARCH OTOLARYNGOL, V122, P985 Chowers I, 2001, OPHTHALMOLOGY, V108, P367, DOI 10.1016/S0161-6420(00)00520-0 Clarijs R, 2001, J PATHOL, V193, P143, DOI 10.1002/path.808 deWaal RMW, 1997, AM J PATHOL, V150, P1951 DVORAK HF, 1988, AM J PATHOL, V133, P95 Ellis LM, 1996, EUR J CANCER, V32A, P2451, DOI 10.1016/S0959-8049(96)00389-9 Fausto N, 2000, AM J PATHOL, V156, P359, DOI 10.1016/S0002-9440(10)64738-4 FINA L, 1990, BLOOD, V75, P2417 Folberg R, 2000, AM J PATHOL, V156, P361, DOI 10.1016/S0002-9440(10)64739-6 Folkman J, 1995, NEW ENGL J MED, V333, P1757 FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 Folkman J, 2001, P NATL ACAD SCI USA, V98, P398, DOI 10.1073/pnas.98.2.398 Fonsatti E, 2001, J CELL PHYSIOL, V188, P1, DOI 10.1002/jcp.1095 Gaze M N, 1990, Clin Oncol (R Coll Radiol), V2, P277, DOI 10.1016/S0936-6555(05)80955-0 Gorsky M, 1998, ORAL SURG ORAL MED O, V86, P715, DOI 10.1016/S1079-2104(98)90209-8 Griffioen AW, 2000, PHARMACOL REV, V52, P237 Hashizume H, 2000, AM J PATHOL, V156, P1363, DOI 10.1016/S0002-9440(10)65006-7 Hendrix MJC, 2001, P NATL ACAD SCI USA, V98, P8018, DOI 10.1073/pnas.131209798 Hewitt RE, 1997, BRIT J CANCER, V75, P221, DOI 10.1038/bjc.1997.37 Hicks MJ, 2000, ORAL ONCOL, V36, P152, DOI 10.1016/S1368-8375(99)00085-8 Holash J, 1999, SCIENCE, V284, P1994, DOI 10.1126/science.284.5422.1994 KATO T, 1987, ARCH DERMATOL, V123, P216, DOI 10.1001/archderm.123.2.216 Larsson KBM, 1999, AUST NZ J SURG, V69, P121, DOI 10.1046/j.1440-1622.1999.01497.x LIOTTA LA, 1992, SCI AM, V266, P54 Makitie T, 1999, J NATL CANCER I, V91, P359, DOI 10.1093/jnci/91.4.359 Maniotis AJ, 1999, AM J PATHOL, V155, P739, DOI 10.1016/S0002-9440(10)65173-5 McDonald DM, 2000, AM J PATHOL, V156, P383, DOI 10.1016/S0002-9440(10)64740-2 McDonald DM, 2000, CANCER METAST REV, V19, P109, DOI 10.1023/A:1026529222845 Nandapalan V, 1998, CLIN OTOLARYNGOL, V23, P107 PAPADIMITRIOU JM, 1975, J PATHOL, V116, P65, DOI 10.1002/path.1711160202 Ponce ML, 1999, CIRC RES, V84, P688 Potter CJ, 2000, TRENDS GENET, V16, P33, DOI 10.1016/S0168-9525(99)01878-8 Sauter B, 1998, J HISTOCHEM CYTOCHEM, V46, P165 Shubik P, 2000, AM J PATHOL, V156, P736, DOI 10.1016/S0002-9440(10)64778-5 Sood AK, 2001, AM J PATHOL, V158, P1279, DOI 10.1016/S0002-9440(10)64079-5 STEINBERG F, 1990, J CANCER RES CLIN, V116, P517, DOI 10.1007/BF01613005 TAKAGI M, 1974, CANCER, V34, P358, DOI 10.1002/1097-0142(197408)34:2<358::AID-CNCR2820340221>3.0.CO;2-D Tanaka F, 2001, CLIN CANCER RES, V7, P3410 TANAKA N, 1994, ORAL SURG ORAL MED O, V78, P81, DOI 10.1016/0030-4220(94)90121-X UMEDA M, 1994, BRIT J ORAL MAX SURG, V32, P39, DOI 10.1016/0266-4356(94)90172-4 VERMEULEN PB, 1995, BRIT J CANCER, V71, P340, DOI 10.1038/bjc.1995.68 Weidner N, 1999, J PATHOL, V189, P297, DOI 10.1002/(SICI)1096-9896(199911)189:3<297::AID-PATH434>3.3.CO;2-F Zhou Y, 1997, J CLIN INVEST, V99, P2139, DOI 10.1172/JCI119387 Lee, YJ Nagai, N Siar, CH Nakano, K Nagatsuka, H Tsujigiwa, H Roan, CH Gunduz, M Histochemical soc inc Seattle
Uncontrolled Keywords: Tumor microvasculature oral malignant melanoma mosaic vessels co-opted vessels vascular channels intracellular channels periodic acid-Schiff stain immunohistochemistry transmission electron microscopy vasculogenic mimicry endothelial-cells tumor angiogenesis mucosal melanoma blood-vessels cancer expression cavity lymphangiogenesis identification
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 09 Jan 2013 01:02
Last Modified: 09 Jan 2013 01:02

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