Expression of notch in a case of osteosarcoma of the maxilla

Kawakami, T.; Siar, C.H.; Ng, K.H.; Shimizu, T.; Okafuji, N.; Kurihara, S.; Hasegawa, H.; Tsujigiwa, H.; Nagatsuka, H.; Nagai, N. (2004) Expression of notch in a case of osteosarcoma of the maxilla. European Journal of Medical Research, 9 (11). pp. 533-535. ISSN 0949-2321

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      Abstract

      In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.

      Item Type: Article
      Creators:
      1. Kawakami, T.
      2. Siar, C.H.
      3. Ng, K.H.
      4. Shimizu, T.
      5. Okafuji, N.
      6. Kurihara, S.
      7. Hasegawa, H.
      8. Tsujigiwa, H.
      9. Nagatsuka, H.
      10. Nagai, N.
      Journal or Publication Title: European Journal of Medical Research
      Additional Information: ISI Document Delivery No.: 882VW Times Cited: 5 Cited Reference Count: 6 Cited References: Blaumueller CM, 1997, CELL, V90, P281, DOI 10.1016/S0092-8674(00)80336-0 GORSKI JP, 1990, J BIOL CHEM, V265, P14956 Schnabel M, 2002, INT J MOL MED, V9, P229 Tezuka K, 2002, J BONE MINER RES, V17, P231, DOI 10.1359/jbmr.2002.17.2.231 Watanabe N, 2003, J BONE MINER METAB, V21, P344, DOI 10.1007/s00774-003-0428-4 ZAGOURAS P, 1995, P NATL ACAD SCI USA, V92, P6414, DOI 10.1073/pnas.92.14.6414 Kawakami, T Siar, CH Ng, KH Shimizu, T Okafuji, N Kurihara, S Hasegawa, H Tsujigiwa, H Nagatsuka, H Nagai, N I holzapfel verlag gmbh Munich
      Uncontrolled Keywords: Osteosarcoma Notch1 peptide cytological characteristics morphogenesis cyto-differentiation morphogenesis regulation factor immunohistochemistry osteoblastic cells differentiation
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 08 Jan 2013 11:59
      Last Modified: 08 Jan 2013 11:59
      URI: http://eprints.um.edu.my/id/eprint/4282

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