Expression of notch in a case of osteosarcoma of the maxilla

Kawakami, T. and Siar, C.H. and Ng, K.H. and Shimizu, T. and Okafuji, N. and Kurihara, S. and Hasegawa, H. and Tsujigiwa, H. and Nagatsuka, H. and Nagai, N. (2004) Expression of notch in a case of osteosarcoma of the maxilla. European Journal of Medical Research, 9 (11). pp. 533-535. ISSN 0949-2321

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Abstract

In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.

Item Type: Article
Additional Information: ISI Document Delivery No.: 882VW Times Cited: 5 Cited Reference Count: 6 Cited References: Blaumueller CM, 1997, CELL, V90, P281, DOI 10.1016/S0092-8674(00)80336-0 GORSKI JP, 1990, J BIOL CHEM, V265, P14956 Schnabel M, 2002, INT J MOL MED, V9, P229 Tezuka K, 2002, J BONE MINER RES, V17, P231, DOI 10.1359/jbmr.2002.17.2.231 Watanabe N, 2003, J BONE MINER METAB, V21, P344, DOI 10.1007/s00774-003-0428-4 ZAGOURAS P, 1995, P NATL ACAD SCI USA, V92, P6414, DOI 10.1073/pnas.92.14.6414 Kawakami, T Siar, CH Ng, KH Shimizu, T Okafuji, N Kurihara, S Hasegawa, H Tsujigiwa, H Nagatsuka, H Nagai, N I holzapfel verlag gmbh Munich
Uncontrolled Keywords: Osteosarcoma Notch1 peptide cytological characteristics morphogenesis cyto-differentiation morphogenesis regulation factor immunohistochemistry osteoblastic cells differentiation
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 08 Jan 2013 03:59
Last Modified: 08 Jan 2013 03:59
URI: http://eprints.um.edu.my/id/eprint/4282

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