Expression of notch in a case of osteosarcoma of the maxilla

Kawakami, T.; Siar, C.H.; Ng, K.H.; Shimizu, T.; Okafuji, N.; Kurihara, S.; Hasegawa, H.; Tsujigiwa, H.; Nagatsuka, H.; Nagai, N. (2004) Expression of notch in a case of osteosarcoma of the maxilla. European Journal of Medical Research, 9 (11). pp. 533-535. ISSN 0949-2321

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      In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.

      Item Type: Article
      1. Kawakami, T.
      2. Siar, C.H.
      3. Ng, K.H.
      4. Shimizu, T.
      5. Okafuji, N.
      6. Kurihara, S.
      7. Hasegawa, H.
      8. Tsujigiwa, H.
      9. Nagatsuka, H.
      10. Nagai, N.
      Journal or Publication Title: European Journal of Medical Research
      Additional Information: ISI Document Delivery No.: 882VW Times Cited: 5 Cited Reference Count: 6 Cited References: Blaumueller CM, 1997, CELL, V90, P281, DOI 10.1016/S0092-8674(00)80336-0 GORSKI JP, 1990, J BIOL CHEM, V265, P14956 Schnabel M, 2002, INT J MOL MED, V9, P229 Tezuka K, 2002, J BONE MINER RES, V17, P231, DOI 10.1359/jbmr.2002.17.2.231 Watanabe N, 2003, J BONE MINER METAB, V21, P344, DOI 10.1007/s00774-003-0428-4 ZAGOURAS P, 1995, P NATL ACAD SCI USA, V92, P6414, DOI 10.1073/pnas.92.14.6414 Kawakami, T Siar, CH Ng, KH Shimizu, T Okafuji, N Kurihara, S Hasegawa, H Tsujigiwa, H Nagatsuka, H Nagai, N I holzapfel verlag gmbh Munich
      Uncontrolled Keywords: Osteosarcoma Notch1 peptide cytological characteristics morphogenesis cyto-differentiation morphogenesis regulation factor immunohistochemistry osteoblastic cells differentiation
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 08 Jan 2013 11:59
      Last Modified: 08 Jan 2013 11:59

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