Huang, James Guoxian and Wong, Yoko Kin Yoke and Chew, Kee Seang and Tanpowpong, Pornthep and Calixto Mercado, Karen Sophia and Reodica, Almida and Rajindrajith, Shaman and Chang, Kai-Chi and Ni, Yen-Hsuan and Treepongkaruna, Suporn and Lee, Way-Seah and Aw, Marion Margaret (2022) Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network. World Journal of Gastroenterology, 28 (17). pp. 1830-1844. ISSN 1007-9327, DOI https://doi.org/10.3748/wjg.v28.i17.1830.
Full text not available from this repository.Abstract
BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease (PIBD). AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform. METHODS Clinical, endoscopic and radiologic data at diagnosis from the registry were extracted between 1(st) January 1995 to 31(st) December 2019. Disease phenotypic characteristics were classified as per the Paris classification system. RESULTS There was a distinct rise in new PIBD cases: Nearly half (48.6%) of the cohort was diagnosed in the most recent 5 years (2015-2019). The ratio of Crohn's disease (CD):Ulcerative colitis (UC):IBD-Unclassified was 55.9%:38.3%:5.8%. The mean age was 9.07 years with a high proportion of very early onset IBD (VEO-IBD) (29.3%) and EO-IBD (52.7%). An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort (6.8%-9.0% Indians in census). Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease (P = 0.003). CD patients presented with significantly more constitutional symptoms (fever, anorexia, malaise/fatigue and muscle-wasting) than UC and higher inflammatory indices (higher C-reactive protein and lower albumin levels). CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity. South Asian CD patients were more likely to have symptomatic perianal disease.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Asia; Inflammatory bowel disease; Paediatrics; Crohn's disease; Ulcerative colitis; Registry |
| Subjects: | R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine > Paediatrics Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Aug 2023 00:52 |
| Last Modified: | 29 Aug 2023 07:57 |
| URI: | http://eprints.um.edu.my/id/eprint/42819 |
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