Localization of oxytalan fiber, type III collagen and BMP family in conventional and desmoplastic ameloblastoma

Inoue, M.; Nagatsuka, H.; Tamamura, R.; Siar, C.H.; Tsujigiwa, H.; Borkosky, S.; Fujii, M.; Nagai, N.; Setsu, K. (2008) Localization of oxytalan fiber, type III collagen and BMP family in conventional and desmoplastic ameloblastoma. Journal of Hard Tissue Biology, 17 (1). pp. 23-30. ISSN 1341-7649

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      The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen and BMP family in DA (n=8) was compared with CA (n=24), and periodontal ligament (PL) (n=8). Oxytalan fibers formed apico-occlusal bundles in PL, thick radial bundles around tumor nests in DA, and as scanty fibers in CA. Type III collagen was identified in PL, strongly expressed in DA stroma, but weakly in CA. BMP-2, -3, -4 and -7 expression patterns in tumor epithelium and stroma were more pronounced in DA (including sites of bone formation), than CA. No immunoreactivity for BMP-5 and -6 were detected. Current findings suggest that the stroma in DA is neoplastic and derived from odontogenic ectomesenchyme, and recommends its reclassification as an odontogenic epithelial-ectomesenchymal neoplasm.

      Item Type: Article
      1. Inoue, M.
      2. Nagatsuka, H.
      3. Tamamura, R.
      4. Siar, C.H.
      5. Tsujigiwa, H.
      6. Borkosky, S.
      7. Fujii, M.
      8. Nagai, N.
      9. Setsu, K.
      Journal or Publication Title: Journal of Hard Tissue Biology
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      Uncontrolled Keywords: Odontogenic neoplasm ameloblastoma matrix proteins BMP family bone morphogenetic protein-2 odontogenic-tumors osteogenic protein-1 tooth morphogenesis developing teeth matrix proteins alpha-6 chains differentiation expression benign
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 09 Jan 2013 09:13
      Last Modified: 09 Jan 2013 09:13
      URI: http://eprints.um.edu.my/id/eprint/4279

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