Inoue, M. and Nagatsuka, H. and Tamamura, R. and Siar, C.H. and Tsujigiwa, H. and Borkosky, S. and Fujii, M. and Nagai, N. and Setsu, K. (2008) Localization of oxytalan fiber, type III collagen and BMP family in conventional and desmoplastic ameloblastoma. Journal of Hard Tissue Biology, 17 (1). pp. 23-30. ISSN 1341-7649, DOI https://doi.org/10.2485/jhtb.17.23.
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Abstract
The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen and BMP family in DA (n=8) was compared with CA (n=24), and periodontal ligament (PL) (n=8). Oxytalan fibers formed apico-occlusal bundles in PL, thick radial bundles around tumor nests in DA, and as scanty fibers in CA. Type III collagen was identified in PL, strongly expressed in DA stroma, but weakly in CA. BMP-2, -3, -4 and -7 expression patterns in tumor epithelium and stroma were more pronounced in DA (including sites of bone formation), than CA. No immunoreactivity for BMP-5 and -6 were detected. Current findings suggest that the stroma in DA is neoplastic and derived from odontogenic ectomesenchyme, and recommends its reclassification as an odontogenic epithelial-ectomesenchymal neoplasm.
| Item Type: | Article |
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| Funders: | UNSPECIFIED |
| Additional Information: | ISI Document Delivery No.: 327HA Times Cited: 4 Cited Reference Count: 39 Cited References: Aberg T, 1997, DEV DYNAM, V210, P383, DOI 10.1002/(SICI)1097-0177(199712)210:4<383::AID-AJA3>3.0.CO;2-C ANDREWS PW, 1994, LAB INVEST, V71, P243 BROOKES SJ, 1995, ARCH ORAL BIOL, V40, P1, DOI 10.1016/0003-9969(94)00135-X BUTLER WT, 1975, J BIOL CHEM, V2, P8907 Coin R, 1999, EUR J ORAL SCI, V107, P487, DOI 10.1046/j.0909-8836.1999.eos107611.x EVERSOLE LR, 1984, J ORAL MAXIL SURG, V42, P735, DOI 10.1016/0278-2391(84)90423-3 Fullmer H M, 1974, J Oral Pathol, V3, P291, DOI 10.1111/j.1600-0714.1974.tb01724.x FULLMER HM, 1958, J HISTOCHEM CYTOCHEM, V6, P425 Gao YH, 1997, J ORAL PATHOL MED, V26, P273, DOI 10.1111/j.1600-0714.1997.tb01236.x HAMNER JE, 1966, ARCH PATHOL, V82, P35 HEIKINHEIMO K, 1994, J DENT RES, V73, P590 HEIKINHEIMO K, 1993, J CLIN INVEST, V91, P1019, DOI 10.1172/JCI116258 HEIKINHEIMO K, 1991, VIRCHOWS ARCH B, V61, P101 Helder MN, 1998, J DENT RES, V77, P545 Jernvall J, 2000, MECH DEVELOP, V92, P19, DOI 10.1016/S0925-4773(99)00322-6 JIN Y, 1990, CLIN ORTHOP RELAT R, V259, P233 Kawai T, 1999, ORAL SURG ORAL MED O, V87, P258, DOI 10.1016/S1079-2104(99)70282-9 Keszler A, 1996, Oral Dis, V2, P228 Kishino M, 2001, J ORAL PATHOL MED, V30, P35, DOI 10.1034/j.1600-0714.2001.300106.x Kramer IR, 1992, HISTOLOGICAL TYPING LUKINMAA PL, 1990, ORAL SURG ORAL MED O, V70, P313, DOI 10.1016/0030-4220(90)90147-K Melrose RJ, 1999, SEMIN DIAGN PATHOL, V16, P271 MORI M, 1991, VIRCHOWS ARCH A, V418, P319, DOI 10.1007/BF01600161 Nagai N, 2001, INT J DEV BIOL, V45, P827 NAGAI N, 1994, EUR J CANC B ORAL ON, P191 Nagatsuka H, 2002, VIRCHOWS ARCH, V441, P392, DOI 10.1007/s00428-002-0658-1 Nakano K, 2002, J ORAL PATHOL MED, V31, P494, DOI 10.1034/j.1600-0714.2002.00162.x NEVLLE BW, 2001, ORAL MAXILLOFACIAL P RAUBENHEIMER EJ, 1995, J ORAL PATHOL MED, V24, P227, DOI 10.1111/j.1600-0714.1995.tb01172.x SAMPSON WJ, 1979, STAIN TECHNOL, V54, P181 Sculean A, 1999, J CLIN PERIODONTOL, V26, P318, DOI 10.1034/j.1600-051X.1999.260510.x SNEAD ML, 1992, ORAL SURG ORAL MED O, V74, P64, DOI 10.1016/0030-4220(92)90217-E THESLEFF I, 1995, INT J DEV BIOL, V39, P35 THESLEFF I, 1979, DEV BIOL, V70, P116, DOI 10.1016/0012-1606(79)90011-3 URIST MR, 1965, SCIENCE, V150, P893, DOI 10.1126/science.150.3698.893 VAINIO S, 1993, CELL, V75, P45, DOI 10.1016/S0092-8674(05)80083-2 Webb PP, 1998, EUR J ORAL SCI, V106, P147 WOZNEY JM, 1992, MOL REPROD DEV, V32, P160, DOI 10.1002/mrd.1080320212 YOSHIKAWA H, 1994, CANCER, V74, P842, DOI 10.1002/1097-0142(19940801)74:3<842::AID-CNCR2820740309>3.0.CO;2-B Inoue, Masahisa Nagatsuka, Hitoshi Tamamura, Ryo Siar, Chong Huat Tsujigiwa, Hidetsugu Borkosky, Silvia Fujii, Masae Nagai, Noriyuki Setsu, Kojun Journal hard tissue biology Minato ku |
| Uncontrolled Keywords: | Odontogenic neoplasm ameloblastoma matrix proteins BMP family bone morphogenetic protein-2 odontogenic-tumors osteogenic protein-1 tooth morphogenesis developing teeth matrix proteins alpha-6 chains differentiation expression benign |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology |
| Depositing User: | Ms Nursyafiqah Abd Malek |
| Date Deposited: | 09 Jan 2013 01:13 |
| Last Modified: | 09 Jan 2013 01:13 |
| URI: | http://eprints.um.edu.my/id/eprint/4279 |
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